DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Joong-Hyup | - |
dc.contributor.advisor | 김중협 | - |
dc.contributor.author | Jeon, Gee-Ho | - |
dc.contributor.author | 전기호 | - |
dc.date.accessioned | 2011-12-13T04:56:56Z | - |
dc.date.available | 2011-12-13T04:56:56Z | - |
dc.date.issued | 1986 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=64987&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32467 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1986.2, [ [iii], 64 p. ] | - |
dc.description.abstract | A C-nucleoside derivative, 5-(5-deoxy-$\beta$-D-erythro-pent-4-enofuransyl)-1,3-dimethyluracil(33), which might be an important intermediate for transformations of pyrimidine ring and/or modifications of sugar moiety, was synthesized from pseudouridine via seven steps in 62\% overall yield. Pseudouridine was sequentially 1,3-dimethylated, 2``,3``-O-isopropylidenated, 5``-deoxy-5``-iodinated, deisopropylidenated, 2``,3``-di-O-acylated, dehydroiodinated, and finally deacylated to yield the desired compound. A derivative, 5-(3(R),4(R)-2,3- dihydroxy-4,5-epoxy-2,3-O-isopropylidene-1-penten-1-yl)-1,3- dimethyluracil(36) was obtained by treatment of 1,3-dimethyl-5-(2,3-O-isopropylidene-5-O-methanesulfonyl- $\beta$-D ribofuranosyl) uracil(34) with potassium tert-butoxide in dimethyl sulfoxide. 5-(5-Deoxy- 2,3-di-O-acetyl-$\beta$-D-erythro-pent-4-enofuranosyl)-1,3-dimethyluracil (32) was examined in the possibility of using it as an intermediate for the synthesis of other compounds by elimination or addition reactions. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis of 5'-deoxypseudouridine derivatives and related reactions | - |
dc.title.alternative | 5'-데옥시슈도우리딘 유도체들의 합성과 관련 반응 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 64987/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000841603 | - |
dc.contributor.localauthor | Kim, Joong-Hyup | - |
dc.contributor.localauthor | 김중협 | - |
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