DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Lee, Sang-Joa | - |
dc.contributor.author | 이상좌 | - |
dc.date.accessioned | 2011-12-13T04:54:50Z | - |
dc.date.available | 2011-12-13T04:54:50Z | - |
dc.date.issued | 1982 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=63275&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32325 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1982.2, [ [iii], 49 p. ] | - |
dc.description.abstract | $N^1$-Ethyl-$N^3$-methyl-isoguanosine, doridosine derivative was prepared. Reaction of 5-amino-(2``, 3``, 5``-tri-O-acetyl- $\beta$ -D-ribofuranosyl) -imidazole-4-carbonitrile with paraformaldehyde following by treatment of sodium borohydride gave 5-methylamino-1-$\beta$-D-ribofuranosyl-imidazole-4-carbonitrile. After protecting the hydroxyl groups in riboside moiety by acetic anhydride-pyridine the reaction of the acetylated compound with ethylisocyanate in dimethylformamide afforded the carbamoyl derivative. Cyclization and deacetylation in methanolic ammonium hydroxide solution at 3-4$^\circ$C yielded $N^1$-ethyl-$N^3$-methyl-isoguanosine, which is a fixed model compound in keto-enol and amino-imino tautomerism. $N^1$-Ethyl-$N^3$-methyl-isoguanosine has a fixed 2-keto and 6-imino form. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis of purine and purine riboside derivatives | - |
dc.title.alternative | 푸린 및 푸린리보사이드 유도체의 합성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 63275/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000801194 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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