DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Yoon, In-Kwon | - |
dc.contributor.author | 윤인권 | - |
dc.date.accessioned | 2011-12-13T04:54:33Z | - |
dc.date.available | 2011-12-13T04:54:33Z | - |
dc.date.issued | 1981 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=62888&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32305 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1981.2, [ [v], 48 p. ] | - |
dc.description.abstract | $N^1$-Alkylisoguanosines, doridosine derivatives, were prepared. Reaction of 4-cyano-5-amino-1-(2``,3``,5``-tri-O-acetyl-$\beta$-D-ribofuranosyl)-imidazole with alkylisocyanate gave the bis carbamoyl derivatives. Cyclization at ca. $4^\circ C$ in methanolic ammonia solution afforded $N^1$-alkylisoguanosine. The structure of $N^1$-alkylisoguanosine was determined to be $N^1$-alkyl-6-amino-2-oxo-9-$\beta$-D-ribofuranosyl purine in water, dioxane, acetonitrile and dimethylsulfoxide solution. The biological activity of $N^1$-ethylisoguanosine was run on the guinea pig atria. $N^1$-ethylisoguanosine showed the same type of activity as $N^1$-methylisoguanosine (Doridosine), but ca. half that of doridosine. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis and characterization of $N^1$-alkylisoguanosine (doridosine derivative) | - |
dc.title.alternative | $N^1$-알킬이소구아노신의 합성및 특성연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 62888/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000791166 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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