DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eunbie | ko |
dc.contributor.author | Kwon, Yongsoo | ko |
dc.contributor.author | Jung, Eunji | ko |
dc.contributor.author | Kim, Yong Joon | ko |
dc.contributor.author | Kim, Changgon | ko |
dc.contributor.author | Hong, Semyeong | ko |
dc.contributor.author | Kim, Joon | ko |
dc.date.accessioned | 2024-09-11T08:00:19Z | - |
dc.date.available | 2024-09-11T08:00:19Z | - |
dc.date.created | 2024-09-11 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.121, no.7 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322913 | - |
dc.description.abstract | Tobacco and alcohol are risk factors for human papillomavirus-negative head and neck squamous cell carcinoma (HPV- HNSCC), which arises from the mucosal epithelium of the upper aerodigestive tract. Notably, despite the mutagenic potential of smoking, HPV- HNSCC exhibits a low mutational load directly attributed to smoking, which implies an undefined role of smoking in HPV- HNSCC. Elevated YAP (Yes- associated protein) mRNA is prevalent in HPV- HNSCC, irrespective of the YAP gene amplification status, and the mechanism behind this upregulation remains elusive. Here, we report that oxidative stress, induced by major risk factors for HPV- HNSCC such as tobacco and alcohol, promotes YAP transcription via TM4SF19 (transmembrane 4 L six family member 19). TM4SF19 modulates YAP transcription by interacting with the GABP (Guanine and adenine- binding protein) transcription factor complex. Mechanistically, oxidative stress induces TM4SF19 dimerization and topology inversion in the endoplasmic reticulum membrane, which in turn protects the GABP beta 1 subunit from proteasomal degradation. Conversely, depletion of TM4SF19 impairs the survival, proliferation, and migration of HPV- HNSCC cells, highlighting the potential therapeutic relevance of targeting TM4SF19. Our findings reveal the roles of the key risk factors of HPV- HNSCC in tumor development via oxidative stress, offering implications for upcoming therapeutic approaches in HPV- HNSCC. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | TM4SF19 controls GABP- dependent <i>YAP</i> transcription in head and neck cancer under oxidative stress conditions | - |
dc.type | Article | - |
dc.identifier.wosid | 001169065400006 | - |
dc.identifier.scopusid | 2-s2.0-85184398136 | - |
dc.type.rims | ART | - |
dc.citation.volume | 121 | - |
dc.citation.issue | 7 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.2314346121 | - |
dc.contributor.localauthor | Kim, Joon | - |
dc.contributor.nonIdAuthor | Kim, Yong Joon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | oral squamous cell carcinoma | - |
dc.subject.keywordAuthor | L6 tetraspanin | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | YAP | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | YES-ASSOCIATED PROTEIN | - |
dc.subject.keywordPlus | HIPPO SIGNALING PATHWAY | - |
dc.subject.keywordPlus | HUMAN-PAPILLOMAVIRUS | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | LIVER-CANCER | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | L6 | - |
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