DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang-Hoon | ko |
dc.contributor.author | Kim, Jihye | ko |
dc.contributor.author | Jung, Sungmin | ko |
dc.contributor.author | Noh, Ji Yun | ko |
dc.contributor.author | Kim, Jinnam | ko |
dc.contributor.author | Park, Heedo | ko |
dc.contributor.author | Song, Young Goo | ko |
dc.contributor.author | Peck, Kyong Ran | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Park, Man-Seong | ko |
dc.contributor.author | Ko, Jae-Hoon | ko |
dc.contributor.author | Song, Joon Young | ko |
dc.contributor.author | Choi, Jun Yong | ko |
dc.contributor.author | Jung, Min Kyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2024-08-23T00:00:11Z | - |
dc.date.available | 2024-08-23T00:00:11Z | - |
dc.date.created | 2024-08-23 | - |
dc.date.created | 2024-08-23 | - |
dc.date.issued | 2024-01 | - |
dc.identifier.citation | SCIENCE IMMUNOLOGY, v.9, no.91 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322391 | - |
dc.description.abstract | Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8(+) T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-gamma-producing CD8(+) T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-gamma-producing CD8(+) T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8(+) T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8(+) T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8(+) T cell responses that recognize epitopes within the spike of newly emerging subvariants. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants | - |
dc.type | Article | - |
dc.identifier.wosid | 001184652400001 | - |
dc.identifier.scopusid | 2-s2.0-85182865740 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 91 | - |
dc.citation.publicationname | SCIENCE IMMUNOLOGY | - |
dc.identifier.doi | 10.1126/sciimmunol.ade6132 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Sang-Hoon | - |
dc.contributor.nonIdAuthor | Kim, Jihye | - |
dc.contributor.nonIdAuthor | Noh, Ji Yun | - |
dc.contributor.nonIdAuthor | Kim, Jinnam | - |
dc.contributor.nonIdAuthor | Park, Heedo | - |
dc.contributor.nonIdAuthor | Song, Young Goo | - |
dc.contributor.nonIdAuthor | Peck, Kyong Ran | - |
dc.contributor.nonIdAuthor | Park, Man-Seong | - |
dc.contributor.nonIdAuthor | Ko, Jae-Hoon | - |
dc.contributor.nonIdAuthor | Song, Joon Young | - |
dc.contributor.nonIdAuthor | Choi, Jun Yong | - |
dc.contributor.nonIdAuthor | Jung, Min Kyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ORIGINAL ANTIGENIC SIN | - |
dc.subject.keywordPlus | VARIANT | - |
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