DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee Hoyoung | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2024-08-23T00:00:09Z | - |
dc.date.available | 2024-08-23T00:00:09Z | - |
dc.date.created | 2024-08-23 | - |
dc.date.created | 2024-08-23 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | IMMUNE NETWORK, v.24, no.1 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322390 | - |
dc.description.abstract | IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions. IL-15 is a homeostatic cytokine essential for the development and maintenance of NK cells and memory CD8+ T cells. In addition, IL-15 plays a critical role in the activation, effector functions, tissue residency, and senescence of CD8+ T cells. IL-15 also activates virtual memory T cells, mucosal-associated invariant T cells and gamma delta T cells. Recently, IL-15 has been highlighted as a major trigger of TCR-independent activation of T cells. This mechanism is involved in T cell-mediated immunopathogenesis in diverse diseases, including viral infections and chronic inflammatory diseases. Deeper understanding of IL-15-mediated T-cell responses and their underlying mechanisms could optimize therapeutic strategies to ameliorate host injury by T cell-mediated immunopathogenesis. This review highlights recent advancements in comprehending the role of IL-15 in relation to T cell responses and immunopathogenesis under various host conditions. | - |
dc.language | English | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.title | IL-15 in T-Cell Responses and Immunopathogenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 001179335500010 | - |
dc.identifier.scopusid | 2-s2.0-85187169010 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | IMMUNE NETWORK | - |
dc.identifier.doi | 10.4110/in.2024.24.e11 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Lee Hoyoung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | Interleukin-15 | - |
dc.subject.keywordAuthor | T-lymphocytes | - |
dc.subject.keywordAuthor | immunopathogenesis | - |
dc.subject.keywordPlus | MEMORY CD8(+) T | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | TISSUE-RESIDENT | - |
dc.subject.keywordPlus | INNATE-LIKE | - |
dc.subject.keywordPlus | BETA-CHAIN | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
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