DC Field | Value | Language |
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dc.contributor.author | Jeon, Seung Hyuck | ko |
dc.contributor.author | Jang, Bum-Sup | ko |
dc.contributor.author | Kim, Dong-Yun | ko |
dc.contributor.author | Kim, Jin Ho | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Kim, In Ah | ko |
dc.date.accessioned | 2024-08-23T00:00:07Z | - |
dc.date.available | 2024-08-23T00:00:07Z | - |
dc.date.created | 2024-08-23 | - |
dc.date.created | 2024-08-23 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, v.118, no.3, pp.790 - 800 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322388 | - |
dc.description.abstract | Purpose: Preclinical studies have shown that radiation therapy modulates antitumor immune responses. However, circulating T-cell responses after radiation therapy in patients with cancer have been poorly characterized. This study aims to explore the changes in circulating T cells after stereotactic body radiation therapy (SBRT). Methods and Materials: Peripheral blood samples of 30 patients with breast cancer who underwent SBRT for bone metastasis were analyzed using multicolor flow cytometry. Phenotypes of PD-1+ CD8+ T cells and regulatory T (TREG) cells were examined. Additionally, plasma protein levels were analyzed using a bead-based immunoassay. Results: Circulating PD-1+ CD8+ T cells, which are enriched for tumor-specific clonotypes, were activated at 1 week after SBRT. However, circulating TREG cells were also activated after SBRT; this pattern was also evident among effector Foxp3hiCD45RA ⠂ TREG cells. We observed no difference in T-cell responses according to the fraction size and number. Notably, activation of TREG cells was more prominent in patients who experienced greater activation of PD-1+ CD8+ T cells. Plasma level changes in TGF-b1, soluble CTLA-4, and soluble 4-1BB at 1 week after SBRT were associated with PD-1+ CD8+ T-cell responses. Activation of TREG cells at 1 week after SBRT was associated with worse progression-free survival. Clinical factors including molecular subtype were not associated with the T-cell responses. Conclusions: SBRT induced activation of both potentially tumor-specific CD8+ T cells and TREG cells, which were tightly associated with each other. These results may support the use of TREG cell-modulating strategies with SBRT to improve the antitumor immune response. (c) 2023 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Dynamic Responses of Circulating T Cells After Stereotactic Body Radiation Therapy for Bone Metastasis in Patients With Breast Cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 001182017600001 | - |
dc.identifier.scopusid | 2-s2.0-85174744716 | - |
dc.type.rims | ART | - |
dc.citation.volume | 118 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 790 | - |
dc.citation.endingpage | 800 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.identifier.doi | 10.1016/j.ijrobp.2023.09.020 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Jang, Bum-Sup | - |
dc.contributor.nonIdAuthor | Kim, Dong-Yun | - |
dc.contributor.nonIdAuthor | Kim, Jin Ho | - |
dc.contributor.nonIdAuthor | Kim, In Ah | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
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