DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jinsu | ko |
dc.contributor.author | Jeong, Yeon Ji | ko |
dc.contributor.author | Park, Seahyung | ko |
dc.contributor.author | Kim, Sungsoo | ko |
dc.contributor.author | Oh, Hyunsik | ko |
dc.contributor.author | Jin, Juae | ko |
dc.contributor.author | Sohn, Jong Woo | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Shin Hee-Sup | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.date.accessioned | 2024-08-18T02:00:05Z | - |
dc.date.available | 2024-08-18T02:00:05Z | - |
dc.date.created | 2024-08-18 | - |
dc.date.created | 2024-08-18 | - |
dc.date.created | 2024-08-18 | - |
dc.date.issued | 2024-07 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.10, no.27 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322347 | - |
dc.description.abstract | Memory processes rely on a molecular signaling system that balances the interplay between positive and negative modulators. Recent research has focused on identifying memory-regulating genes and their mechanisms. Phospholipase C beta 1 (PLC beta 1), highly expressed in the hippocampus, reportedly serves as a convergence point for signal transduction through G protein-coupled receptors. However, the detailed role of PLC beta 1 in memory function has not been elucidated. Here, we demonstrate that PLC beta 1 in the dentate gyrus functions as a memory suppressor. We reveal that mice lacking PLC beta 1 in the dentate gyrus exhibit a heightened fear response and impaired memory extinction, and this excessive fear response is repressed by upregulation of PLC beta 1 through its overexpression or activation using a newly developed optogenetic system. Last, our results demonstrate that PLC beta 1 overexpression partially inhibits exaggerated fear response caused by traumatic experience. Together, PLC beta 1 is crucial in regulating contextual fear memory formation and potentially enhancing the resilience to trauma-related conditions. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability | - |
dc.type | Article | - |
dc.identifier.wosid | 001262993200002 | - |
dc.identifier.scopusid | 2-s2.0-85197684315 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 27 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.adj4433 | - |
dc.contributor.localauthor | Sohn, Jong Woo | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Kim, Sungsoo | - |
dc.contributor.nonIdAuthor | Oh, Hyunsik | - |
dc.contributor.nonIdAuthor | Shin Hee-Sup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | NMDA RECEPTOR | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | EXTINCTION | - |
dc.subject.keywordPlus | RETRIEVAL | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | ACQUISITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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