DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 신의철 | - |
dc.contributor.author | Kim, Woo-Joong | - |
dc.contributor.author | 김우중 | - |
dc.date.accessioned | 2024-08-08T19:31:29Z | - |
dc.date.available | 2024-08-08T19:31:29Z | - |
dc.date.issued | 2024 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1099369&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/322121 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2024.2,[ii, 60 p. :] | - |
dc.description.abstract | Lupus nephritis is a common and severe manifestation of systemic lupus erythematosus. Despite aggressive treatment strategies, over half of the patients fail to achieve remission. Suboptimal disease control often results in irreversible nephron loss and progression to end-stage kidney disease. Additionally, cumulative exposure to potent non-selective immunosuppressants and corticosteroid burden are associated with long-term toxicities and organ damage accrual. In this thesis, we investigate the transcriptional properties of circulating immune cells in patients with class III/IV lupus nephritis undergoing induction therapy. Our research focuses on identifying a distinct transcriptional signature associated with treatment response, utilizing single-cell transcriptomic analysis of peripheral blood mononuclear cells. This study aims to contribute to the understanding of treatment efficacy and potentially inform more targeted therapeutic strategies. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 루푸스 신염▼a면역 세포▼a단일세포 전사체 분석▼a가중 상관 네트워크 | - |
dc.subject | Lupus nephritis▼aInduction therapy▼aTranscriptional signature▼aSingle-cell transcriptomic analysis | - |
dc.title | Discovering a transcriptional signature of monocytes associated with treatment responses in lupus nephritis patients | - |
dc.title.alternative | 루푸스 신염의 치료 반응과 연관된 말초혈액 단핵구 전사체 분석 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Shin, Eui-Cheol | - |
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