DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박수형 | - |
dc.contributor.author | Lee, Jeongsoo | - |
dc.contributor.author | 이정수 | - |
dc.date.accessioned | 2024-08-08T19:31:28Z | - |
dc.date.available | 2024-08-08T19:31:28Z | - |
dc.date.issued | 2024 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1099366&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/322118 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2024.2,[iv, 50 p. :] | - |
dc.description.abstract | An elusive subset of memory B cells, known as atypical memory B cells, has been identified in various chronic inflammatory conditions and infections, with their specific role in the humoral immune response still under active investigation. In my study, I isolated RBD-specific B cells using fluorochrome-conjugated streptavidin tetramers, conducting LIBRA-seq and BCR-seq analyses. Kinetic data from PBMC samples of BNT162b2 vaccine recipients revealed a rising frequency of atypical memory B cells among RBD-specific B cells after each vaccine dose. Additionally, my in-depth analysis unveiled distinct gene regulatory networks, with T-bet as the most subset-specific, correlated with unique surface phenotypes and chemokine profiles. Gene Set Enrichment Analysis highlighted activation-prone pathways and in-vitro stimulation resulted in robust antibody-secreting cell differentiation and RBD-binding IgG antibody secretion compared with classical memory B cells, suggesting a potential role for these atypical memory B cells in future vaccine design and strategy against viral infections due to their effector memory features in cognate antigen challenges. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 기억 B 세포▼aT-bet▼a효과기 기억세포 | - |
dc.subject | Memory B cell▼aT-bet▼aEffector memory | - |
dc.title | Study on SARS-CoV-2-specific atypical memory B cells induced by vaccination exhibiting robust effector functions | - |
dc.title.alternative | SARS-CoV-2 백신에 의해 유도되는 비정형 기억 B 세포의 면역 특성 및 기능에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Park, Su-Hyung | - |
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