DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이흥규 | - |
dc.contributor.author | Kim, Chae Won | - |
dc.contributor.author | 김채원 | - |
dc.date.accessioned | 2024-07-26T19:31:35Z | - |
dc.date.available | 2024-07-26T19:31:35Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1052039&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/321143 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2023.2,[iv, 89 p. :] | - |
dc.description.abstract | however, it can also modulate gut microbiota leading to changes in microbiome-derived metabolites. In this study, I found that a HSD altered the composition of gut microbiota, including a large increase in the Bacteroides vulgatus population, resulting in the exacerbation of glioma brain tumors. Levels of propionate, a short-chain fatty acid (SCFA) produced by B. vulgatus, were elevated in the gut of mice fed a HSD. I determined that propionate administration induced glioma exacerbation as determined by reduced survival. In addition, propionate induced pseudohypoxia in glioma cells resulting in enhanced TGF-β signaling. Within the tumor microenvironment (TME), this elevated TGF-β signaling promoted the differentiation of monocyte-derived macrophages into an anti-inflammatory subset. These results indicate that a metabolite derived from the gut microbiota that is elevated under conditions of a HSD has a negative impact on the brain tumor microenvironment resulting in reduced survival in a murine glioma model. | - |
dc.description.abstract | A high-salt diet (HSD) is a common westernized diet that affects various organs via osmolality enhancement | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 장내 공생미생물▼a고염식▼a뇌종양▼a프로피온산▼a가성 저산소증 | - |
dc.subject | Gut microbiome▼aHigh-salt diet▼aGlioma▼aPropionate▼aPseudohypoxia | - |
dc.title | Gut microbiota-derived propionate by a high-salt diet modulates brain tumor microenvironment | - |
dc.title.alternative | 고염식으로 인한 장내 미생물 유래 프로피온산의 뇌종양 환경 조절 기전 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Lee, Heung Kyu | - |
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