DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Hee-Seung | - |
dc.contributor.advisor | 이희승 | - |
dc.contributor.author | Lim, Ji-Soo | - |
dc.contributor.author | 임지수 | - |
dc.date.accessioned | 2011-12-13T04:51:39Z | - |
dc.date.available | 2011-12-13T04:51:39Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=308941&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32111 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2009.2, [ ⅸ, 70 p. ] | - |
dc.description.abstract | Part Ⅰ. Cation-$\pi$ interaction, one of the most famous noncanonical noncovalent interactions is used in natural protein folding system. Nevertheless, utilizing cation-$\pi$ interaction to design foldamers has not been reported yet. So, we used cation-$\pi$ interaction to design 14-helical $\beta^3$ -peptides that are stable in aqueous solution. Until recently, only $\beta^3$ -peptide stabilized by salt bridge on one or two helical faces showed 14-helical propensity in water. We compared the helical stability of $\beta^3$ -peptides stabilized by cation-$\pi$ interaction (Trp/Orn) with those stabilized by salt-bridge (Glu/Orn) using spectroscopic methods and confirmed 14-helical structure through NMR study. Our newly designed $\beta^3$ -peptide has overall net positive charge, so it is expected to improve cell permeability for biological applications. Part Ⅱ. We have further modified $\gamma^3$ -PNA monomer, which binds RNA more specifically as well as in an antiparallel fashion. Elongation of base linker led to $\gamma^3$ -hPNA, which differentiate RNA from DNA when partially incorporated. Changing to positively charged backbone ($\gamma^3$ -ANA) and 1,2,3-triazole backbone ($\gamma^3$ -triPhe) also succeeded. Improvement in synthetic efficiency and structural analysis is studying further now. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Biomimetic | - |
dc.subject | PNA | - |
dc.subject | \beta-peptide | - |
dc.subject | \gamma-amino acid | - |
dc.subject | 생체유사 | - |
dc.subject | 피엔에이 | - |
dc.subject | 베타펩타이드 | - |
dc.subject | 감마아미노산 | - |
dc.subject | Biomimetic | - |
dc.subject | PNA | - |
dc.subject | \beta-peptide | - |
dc.subject | \gamma-amino acid | - |
dc.subject | 생체유사 | - |
dc.subject | 피엔에이 | - |
dc.subject | 베타펩타이드 | - |
dc.subject | 감마아미노산 | - |
dc.title | Design and synthesis of biomimetic scaffold based on $\beta$- and mixed $\gamma-/\delta$ - amino acids | - |
dc.title.alternative | 베타- 및 감마-/델타- 아미노산을 기반으로 한 생체유사 골격의 결합 및 합성 방법에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 308941/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 020073471 | - |
dc.contributor.localauthor | Lee, Hee-Seung | - |
dc.contributor.localauthor | 이희승 | - |
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