DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이현주 | - |
dc.contributor.author | Kim, Subeen | - |
dc.contributor.author | 김수빈 | - |
dc.date.accessioned | 2024-07-26T19:31:20Z | - |
dc.date.available | 2024-07-26T19:31:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1051096&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/321076 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 전기및전자공학부, 2022.8,[iv, 38 p. :] | - |
dc.description.abstract | Focused ultrasound stimulation (FUS) is a promising therapeutic modality for noninvasive targeted neuromodulation. Consequently, there is a growing need to investigate the direct neuronal effects of FUS using various imaging techniques. Functional magnetic resonance imaging (fMRI) is a well-established and mature technology that is theoretically compatible with FUS and is capable of whole-brain monitoring in real-time. However, existing ultrasonic stimulation systems are incompatible with high-resolution fMRI (> 7T) for small animals because commercially-available ultrasound transducers are generally bulky and cause external image artifacts under high magnetic field strength. This paper reports a miniaturized, MR-compatible ultrasound transducer system for simultaneous monitoring of FUS-induced acoustic effects using high resolution (9.4 T) fMRI in mice. Our system integrated (1) MR-compatible materials, (2) robust packaging and interface designs for ultrasound transmission, and (3) electromagnetic noise reduction techniques. Using this system, we demonstrate artifact-free echo-planar imaging (EPI) signal changes due to ultrasound brain stimulation in vivo. Our results provide a critical demonstration of miniaturized MR-compatible ultrasound stimulation systems for in vivo studies in small animals usinghigh-resolution functional imaging. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 초음파 자극▼a기능적 자기공명영상▼a전임상연구▼a영상 결함 최소화 | - |
dc.subject | Focused ultrasound stimulation▼aFunctional magnetic resonance imaging▼aPreclinical study▼aLow-artifact system | - |
dc.title | Development of MR-compatible ultrasound brain stimulation system and monitoring of acoustic effects in mice | - |
dc.title.alternative | 자기공명영상장치와 호환 가능한 생쥐용 초음파 뇌 자극 시스템 개발 및 영상 신호 분석 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :전기및전자공학부, | - |
dc.contributor.alternativeauthor | Lee, Hyunjoo Jenny | - |
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