DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Jie-Oh | - |
dc.contributor.advisor | 이지오 | - |
dc.contributor.author | Oh, Se-Cheol | - |
dc.contributor.author | 오세철 | - |
dc.date.accessioned | 2011-12-13T04:50:52Z | - |
dc.date.available | 2011-12-13T04:50:52Z | - |
dc.date.issued | 2007 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=265090&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32058 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2007. 2, [ iii, 43 p. ] | - |
dc.description.abstract | Variable Lymphocyte Receptors (VLRs) are recently-discovered Leucine-Rich Repeat (LRR) family proteins that mediate adaptive immune responses in jawless fish. Phylogenetically it is the oldest adaptive immune receptor and the first one with a non-immunoglobulin fold. We present the crystal structures of one VLR-A and one VLR-B clones from the inshore hagfish. The hagfish VLRs have the characteristic horseshoe shaped structure of LRR family proteins. The backbone structures of their LRR modules are highly homologous and the sequence variation is concentrated in the concave surface of the protein. The conservation of key residues suggests that our structures are likely to represent the LRR structures of the entire repertoire of jawless fish VLRs. The analysis of sequence variability, prediction of protein interaction surfaces, amino acid composition analysis and structural comparison with other LRR proteins, suggest that the hypervariable concave surface is the most probable antigen binding site of the VLR. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Variable Lymphocyte Receptor | - |
dc.subject | X-ray Crystallography | - |
dc.subject | Adaptive immune system | - |
dc.subject | 생화학 | - |
dc.subject | 면역학 | - |
dc.subject | X선 결정법 | - |
dc.subject | Biochemistry | - |
dc.title | Structural diversity of the hagfish variable Lymphocyte receptors | - |
dc.title.alternative | Hagfish 의 Variable Lymphocyte Receptors 의 구조적 다양성에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 265090/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 020053351 | - |
dc.contributor.localauthor | Lee, Jie-Oh | - |
dc.contributor.localauthor | 이지오 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.