DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박지호 | - |
dc.contributor.author | Kim, Hyoyeon | - |
dc.contributor.author | 김효연 | - |
dc.date.accessioned | 2024-07-25T19:30:12Z | - |
dc.date.available | 2024-07-25T19:30:12Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1044780&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/320380 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2021.2,[iii, 28 p. :] | - |
dc.description.abstract | Combination therapy with immunologic adjuvants presents a promising method to improve the efficacy of anti-OX40 cancer immunotherapy. Previous studies have shown that adjuvant-induced inflammatory signals and T cell OX40 expression can enhance OX40 stimulation by anti-OX40 mAb. However, these studies have not taken into consideration the timecourse of OX40 and expression and activity, which is a critical factor in the strength of OX40 signaling. As T cells upregulate OX40 on their surface with delayed kinetics upon activation, a delay should exist between the delivery of the activating adjuvant and anti-OX40 mAb as well. This study proposes a hydrogel-based release system for the co-delivery of STING agonists and anti-OX40 mAb. The pore size of the hydrogel system is optimized to take advantage of the size difference of the two payloads, producing a burst release of STING agonists and a delayed slow release of mAb. Local injection of this system at the tumor site will allow for anti-OX40 delivery when intratumoral OX40 expression is at its peak, maximizing therapeutic efficiency of combination therapy. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 항암 면역치료▼a항-OX40 항체▼aSTING 작용제▼a하이드로젤 | - |
dc.subject | Cancer immunotherapy▼aAnti-OX40 antibody▼aSTING agonist▼aHydrogel | - |
dc.title | Development of a drug delivery system for efficient sting agonist and anti-ox40 combination therapy | - |
dc.title.alternative | 효율적인 STING 작용제와 항-OX40 항체의 복합치료를 위한 전달 시스템 개발 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | Park, Ji-Ho | - |
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