DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chun, Min Young | ko |
dc.contributor.author | Chung, Seok Jong | ko |
dc.contributor.author | Kim, Su Hong | ko |
dc.contributor.author | Park, Chan Wook | ko |
dc.contributor.author | Jeong, Seong Ho | ko |
dc.contributor.author | Lee, Hye Sun | ko |
dc.contributor.author | Lee, Phil Hyu | ko |
dc.contributor.author | Sohn, Young H. | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Kim, Yun Joong | ko |
dc.date.accessioned | 2024-06-07T08:01:22Z | - |
dc.date.available | 2024-06-07T08:01:22Z | - |
dc.date.created | 2023-11-30 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | ANNALS OF NEUROLOGY, v.95, no.2, pp.388 - 399 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/10203/319672 | - |
dc.description.abstract | Objective: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD). Methods: We recruited patients with newly diagnosed and nonmedicated PD and healthy participants who underwent dual phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scans. Patients were classified into 3 groups according to hippocampal perfusion measured by standard uptake value ratios (SUVRs): (1) PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), (2) PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and (3) the remaining patients (PD-hippo-normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and risk of dementia conversion among the groups. Results: We included 235 patients (PD-hippo-hypo, n = 21; PD-hippo-normal, n = 157; PD-hippo-hyper, n = 57) and 48 healthy participants. Patients in the PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD-hippo-hypo group had a higher risk of dementia conversion compared to the PD-hippo-normal (hazard ratio = 2.59, p = 0.013) and PD-hippo-hyper (hazard ratio = 3.73, p = 0.006) groups, despite similar cognitive performance at initial assessment between groups. Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD. ANN NEUROL 2024;95:388–399. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase 18F-FP-CIT Positron Emission Tomography Study | - |
dc.type | Article | - |
dc.identifier.wosid | 001114875200001 | - |
dc.identifier.scopusid | 2-s2.0-85178067266 | - |
dc.type.rims | ART | - |
dc.citation.volume | 95 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 388 | - |
dc.citation.endingpage | 399 | - |
dc.citation.publicationname | ANNALS OF NEUROLOGY | - |
dc.identifier.doi | 10.1002/ana.26827 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.nonIdAuthor | Chun, Min Young | - |
dc.contributor.nonIdAuthor | Chung, Seok Jong | - |
dc.contributor.nonIdAuthor | Park, Chan Wook | - |
dc.contributor.nonIdAuthor | Jeong, Seong Ho | - |
dc.contributor.nonIdAuthor | Lee, Hye Sun | - |
dc.contributor.nonIdAuthor | Lee, Phil Hyu | - |
dc.contributor.nonIdAuthor | Sohn, Young H. | - |
dc.contributor.nonIdAuthor | Kim, Yun Joong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article; Early Access | - |
dc.subject.keywordPlus | CLINICAL DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | INCIDENT DEMENTIA | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | RESERVE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | AMYGDALA | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | SYSTEM | - |
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