DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Kim, Yun-Bong | - |
dc.contributor.author | 김윤봉 | - |
dc.date.accessioned | 2011-12-13T04:48:23Z | - |
dc.date.available | 2011-12-13T04:48:23Z | - |
dc.date.issued | 2002 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=173592&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/31898 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2002.2, [ iii, 45 p. ] | - |
dc.description.abstract | Echinomycin is well known to natural product which shows strong antibiotic activity. Its outer quinoxaline rings have a important role of bis-intercalating around the DNA, and the $C_2$-symmetric peptide also has an interesting biological activity. Connection with the synthesis of echinomycin analogue, new quinoxaline antibiotics which have a cyclic octadepsipeptide but different inner bridge $(-CH_2-S-CH_2-S-CH_2-)$ havw been synthesized. $C_2$-symmetric cyclic octadepsipeptide have been prepared from tradepsipeptide, Cbz-D-Ser[H-Ala-MeCys(Bam)-Me-Val]-OPa, as a key intermediate. New quinoxalyl compounds (66 and 69) were prepared from 55 through 3 steps. Their oxidized forms (67, 68, 70 and 71) were also prepared by oxidation with m-CPBA or dimethyldioxirane. Cytotoxcities of YK-2000 - 2003 against human cancer cell were measured. The YK-2000(66) shows a similar cytotoxicity to echinomycin. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | DNA intercalator | - |
dc.subject | anti-cancer activity | - |
dc.subject | Echinomycin | - |
dc.subject | Octadepsipeptide | - |
dc.subject | 인터킬레이터 | - |
dc.subject | 옥타뎁시펩타이드 | - |
dc.subject | 항암특성 | - |
dc.subject | 이치노마이신 | - |
dc.title | Synthesis and study on biological activity of quinoxalyl octadepsipeptide | - |
dc.title.alternative | 퀴녹살릴 옥타뎁시펩타이드의 합성 및 생체활성의 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 173592/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 020003112 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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