Engineering of Yarrowia lipolytica as a platform strain for producing adipic acid from renewable resource

Cited 1 time in webofscience Cited 0 time in scopus
  • Hit : 68
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorLee, Sang Minko
dc.contributor.authorLee, Ju Youngko
dc.contributor.authorHahn, Ji-Sookko
dc.contributor.authorBaek, Seung-Hoko
dc.date.accessioned2024-04-03T02:00:16Z-
dc.date.available2024-04-03T02:00:16Z-
dc.date.created2024-04-03-
dc.date.issued2024-01-
dc.identifier.citationBIORESOURCE TECHNOLOGY, v.391-
dc.identifier.issn0960-8524-
dc.identifier.urihttp://hdl.handle.net/10203/318921-
dc.description.abstractThere is an increasing demand for bio-based dicarboxylic acids (DCA) as an eco-friendly alternatives to chemically synthesized DCA. Adipic acid, which is not naturally produced by microorganisms, is an essential DCA with significant industrial importance. This study aimed to develop a platform strain using Yarrowia lipolytica for efficient bioconversion of renewable resources into adipic acid. To prevent the complete oxidation of adipic acid, peroxisomal beta-oxidation was engineered by selectively disrupting acyl-CoA oxidases. Furthermore, to-oxidation activity was improved via introducing an additional copy of cytochrome P450 monooxygenase (ALK5) and reductase (CPR1) with fatty alcohol oxidase (FAO1). The production phase used SP92D medium in a two-stage bioconversion process, during which the engineered strain exhibited the highest production level, achieving a remarkable 9.7-fold increase compared to that of the parental strain. To our knowledge, this is the first report demonstrating that engineered Y. lipolytica can produce adipic acid from fatty acid methyl esters.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.titleEngineering of Yarrowia lipolytica as a platform strain for producing adipic acid from renewable resource-
dc.typeArticle-
dc.identifier.wosid001114846700001-
dc.identifier.scopusid2-s2.0-85176612849-
dc.type.rimsART-
dc.citation.volume391-
dc.citation.publicationnameBIORESOURCE TECHNOLOGY-
dc.identifier.doi10.1016/j.biortech.2023.129920-
dc.contributor.localauthorLee, Ju Young-
dc.contributor.nonIdAuthorLee, Sang Min-
dc.contributor.nonIdAuthorHahn, Ji-Sook-
dc.contributor.nonIdAuthorBaek, Seung-Ho-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorYarrowia lipolytica-
dc.subject.keywordAuthorAdipic acid-
dc.subject.keywordAuthorMetabolic engineering-
dc.subject.keywordAuthorTwo-stage bioconversion-
dc.subject.keywordAuthorFatty acid methyl ester (FAME)-
dc.subject.keywordPlusFAMILY-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 1 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0