DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rho, Hye-Won | ko |
dc.contributor.author | Lee, Ji-Na | ko |
dc.contributor.author | Kim, Hyung-Rho | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.date.accessioned | 2024-03-27T01:00:30Z | - |
dc.date.available | 2024-03-27T01:00:30Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2000-03 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.32, no.1, pp.12 - 17 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318882 | - |
dc.description.abstract | Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these p-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-inudced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | Protective mechanism of glucose against alloxan-induced β-cell damage: Pivotal role of ATP | - |
dc.type | Article | - |
dc.identifier.wosid | 000086233500003 | - |
dc.identifier.scopusid | 2-s2.0-0034737784 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 12 | - |
dc.citation.endingpage | 17 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/emm.2000.3 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Rho, Hye-Won | - |
dc.contributor.nonIdAuthor | Lee, Ji-Na | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Rho | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | glucose | - |
dc.subject.keywordAuthor | ATP | - |
dc.subject.keywordAuthor | alloxan | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | DNA fragmentation | - |
dc.subject.keywordPlus | DNA STRAND BREAKS | - |
dc.subject.keywordPlus | PANCREATIC-ISLETS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | FRAGMENTATION | - |
dc.subject.keywordPlus | ENDONUCLEASE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | INVIVO | - |
dc.subject.keywordPlus | NUCLEI | - |
dc.subject.keywordPlus | LINE | - |
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