DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.contributor.author | Park, Eun-Kyung | ko |
dc.contributor.author | Ryu, Do-Gon | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-27T01:00:26Z | - |
dc.date.available | 2024-03-27T01:00:26Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2002-03 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.34, no.1, pp.32 - 37 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318881 | - |
dc.description.abstract | Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP). D4-GDI is a GDP dissociation inhibitor for the Ras-related Rho family GTPase in hematopoietic cells. Here we report that D4-GDI is a substrate for the caspase-3. D4-GDI was cleaved to a 23 kDa fragment by daunorubicin treatment in HL-60 cells with kinetics that parallel the onset of apoptosis. D4-GDI cleavage as well as DNA fragmentation was inhibited by treatment with Ac-DEVD-CHO but not with Ac-YVAD-CHO, a caspase-1 inhibitor. These data suggest that D4-GDI of Rho family GTPase may be regulated during apoptosis through the caspase-3 mediated cleavage of the GDI protein. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000175095200005 | - |
dc.identifier.scopusid | 2-s2.0-0037204426 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 32 | - |
dc.citation.endingpage | 37 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/emm.2002.5 | - |
dc.identifier.kciid | ART000860004 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.contributor.nonIdAuthor | Park, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Ryu, Do-Gon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | daunorubicin | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.subject.keywordAuthor | D4-GDI | - |
dc.subject.keywordAuthor | poly(ADP-ribose) polymerase | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | GDP-DISSOCIATION INHIBITOR | - |
dc.subject.keywordPlus | GTP-BINDING PROTEINS | - |
dc.subject.keywordPlus | LY-GDI | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | SELECTIVE ACTIVATION | - |
dc.subject.keywordPlus | RHO | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | GTPASES | - |
dc.subject.keywordPlus | DOWNSTREAM | - |
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