DC Field | Value | Language |
---|---|---|
dc.contributor.author | Duplomb, Laurence | ko |
dc.contributor.author | Lee, Young | ko |
dc.contributor.author | Wang, May-Yun | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Takaishi, Kiyosumi | ko |
dc.contributor.author | Agarwal, Anil K. | ko |
dc.contributor.author | Unger, Roger H. | ko |
dc.date.accessioned | 2024-03-27T01:00:21Z | - |
dc.date.available | 2024-03-27T01:00:21Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.313, no.3, pp.594 - 599 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318880 | - |
dc.description.abstract | To determine if increased local production of glucocorticoids by the pancreatic islets might play a role in the spontaneous noninsulin-dependent diabetes mellitus of obesity, we compared islet 11beta-HSD-1 mRNA and activity in islets of obese prediabetic and diabetic Zucker Diabetic Fatty (ZDF) (falfa) rats and lean wild-type (+/+) controls. In diabetic rat islets, both mRNA and enzymatic activity of the enzyme were increased in proportion to the hyperglycemia. Troglitazone (TGZ) treatment, beginning at 6 weeks of age, prevented the hyperglycemia, the hyperlipidemia, and the increase in 11beta-HSD-1. To determine if the metabolic abnormalities had caused the 11beta-HSD-1 increase, prediabetic islets were cultured in high or low glucose or in 2:1 oleate:palmitate for 3 days. Neither nutrient enhanced the expression of 11beta-HSD-1. We conclude that 11beta-HSD-1 expression and activity are increased in islets of diabetic, but not prediabetic ZDF rats, and that TGZ prevents both the increase in 11beta-HSD-1 and the diabetes. (C) 2003 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Increased expression and activity of 11β-HSD-1 in diabetic islets and prevention with troglitazone | - |
dc.type | Article | - |
dc.identifier.wosid | 000187894400023 | - |
dc.identifier.scopusid | 2-s2.0-0347064002 | - |
dc.type.rims | ART | - |
dc.citation.volume | 313 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 594 | - |
dc.citation.endingpage | 599 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2003.11.160 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Duplomb, Laurence | - |
dc.contributor.nonIdAuthor | Lee, Young | - |
dc.contributor.nonIdAuthor | Wang, May-Yun | - |
dc.contributor.nonIdAuthor | Takaishi, Kiyosumi | - |
dc.contributor.nonIdAuthor | Agarwal, Anil K. | - |
dc.contributor.nonIdAuthor | Unger, Roger H. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | glucocorticoid | - |
dc.subject.keywordAuthor | 11 beta-HSD-1 | - |
dc.subject.keywordAuthor | ZDF (falfa) rats | - |
dc.subject.keywordAuthor | islets | - |
dc.subject.keywordAuthor | Cushing&apos | - |
dc.subject.keywordAuthor | s syndrome and obesity | - |
dc.subject.keywordPlus | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | - |
dc.subject.keywordPlus | CORTISOL METABOLISM | - |
dc.subject.keywordPlus | INSULIN RESISTANCE | - |
dc.subject.keywordPlus | VISCERAL OBESITY | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LIVER | - |
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