DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류도곤 | ko |
dc.contributor.author | 권강범 | ko |
dc.contributor.author | 김은경 | ko |
dc.contributor.author | 박성주 | ko |
dc.contributor.author | 송호준 | ko |
dc.contributor.author | 박병현 | ko |
dc.contributor.author | 박진우 | ko |
dc.date.accessioned | 2024-03-26T09:00:09Z | - |
dc.date.available | 2024-03-26T09:00:09Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2005-12 | - |
dc.identifier.citation | 동의생리병리학회지, v.19, no.6, pp.1552 - 1556 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318874 | - |
dc.description.abstract | Silymarin has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that silymarin induced apoptosis in androgen-independent prostate cancer DU145 cells as confirmed by DNA fragmentation. Our data demonstrated that silymarin-induced apoptotic cell death was accompanied by activation of caspase-3 and subsequent cleavages of its substrates, poly(ADP-ribose) polymerase (PARP) in a time- and concentration-dependent manner. Also, silymarin-induced apoptotic mechanism of DU145 cells involved the induction of Par-4 protein expression. Taken together, these results suggest that silymarin induces the activation of caspase-3, degradation of PARP, increase of Par-4 expression, and eventually leads to apoptotic cell death. | - |
dc.language | Korean | - |
dc.publisher | 한의병리학회 | - |
dc.title | 전립선 암세포에서 silymarin의 고사 유도 효과 및 기전 연구 | - |
dc.title.alternative | Apoptotic Effects and Mechanism Study of Silymarin in DU145 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1552 | - |
dc.citation.endingpage | 1556 | - |
dc.citation.publicationname | 동의생리병리학회지 | - |
dc.identifier.kciid | ART001123827 | - |
dc.contributor.localauthor | 박병현 | - |
dc.contributor.nonIdAuthor | 류도곤 | - |
dc.contributor.nonIdAuthor | 권강범 | - |
dc.contributor.nonIdAuthor | 김은경 | - |
dc.contributor.nonIdAuthor | 박성주 | - |
dc.contributor.nonIdAuthor | 송호준 | - |
dc.contributor.nonIdAuthor | 박진우 | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | silymarin | - |
dc.subject.keywordPlus | DU145 cells | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | caspase-3 | - |
dc.subject.keywordPlus | PARP | - |
dc.subject.keywordPlus | Par-4 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.