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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells

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dc.contributor.authorKoo, Jeung-Hyunko
dc.contributor.authorLee, Ikjaeko
dc.contributor.authorYun, Seok-Kweonko
dc.contributor.authorKim, Han-Ukko
dc.contributor.authorPark, Byung-Hyunko
dc.contributor.authorPark, Jin-Wooko
dc.date.accessioned2024-03-25T01:01:57Z-
dc.date.available2024-03-25T01:01:57Z-
dc.date.created2024-03-21-
dc.date.issued2010-03-
dc.identifier.citationMOLECULAR MEDICINE REPORTS, v.3, no.2, pp.281 - 285-
dc.identifier.issn1791-2997-
dc.identifier.urihttp://hdl.handle.net/10203/318845-
dc.description.abstractThe purpose of this Study was to determine whether saponified Sunflower and safflower oils can potentially be used as whitening agents, and to investigate their underlying mechanisms. Saponified sunflower (sap-SU) and safflower (sap-SA) oils close-dependently inhibited istobutylmethylxanthine-induced melanogenesis is B16 melanoma cells, with no cytotoxicity. This decrease in melanin production was correlated with reduced enzyme activity and decreased mRNA and protein levels of tyrosinase. mRNA levels of microphthalmia-associated transcription factor and tyrosinase-related proteins I and 2 were also decreased by sap-SU and sap-SA, indicating the regulation of tyrosinase at the transcriptional level. Taken together, these results suggest that sap-SU and sap-SA can potentially be used as cosmetic whitening agents.-
dc.languageEnglish-
dc.publisherSPANDIDOS PUBL LTD-
dc.titleSaponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells-
dc.typeArticle-
dc.identifier.wosid000274822200013-
dc.identifier.scopusid2-s2.0-77950786771-
dc.type.rimsART-
dc.citation.volume3-
dc.citation.issue2-
dc.citation.beginningpage281-
dc.citation.endingpage285-
dc.citation.publicationnameMOLECULAR MEDICINE REPORTS-
dc.identifier.doi10.3892/mmr_00000252-
dc.contributor.localauthorPark, Byung-Hyun-
dc.contributor.nonIdAuthorKoo, Jeung-Hyun-
dc.contributor.nonIdAuthorLee, Ikjae-
dc.contributor.nonIdAuthorYun, Seok-Kweon-
dc.contributor.nonIdAuthorKim, Han-Uk-
dc.contributor.nonIdAuthorPark, Jin-Woo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorsaponification-
dc.subject.keywordAuthorsunflower oil-
dc.subject.keywordAuthorsafflower oil-
dc.subject.keywordAuthormelanogenesis-
dc.subject.keywordAuthorB16 melanoma cells-
dc.subject.keywordPlusSKIN PIGMENTATION-
dc.subject.keywordPlusTYROSINASE-
dc.subject.keywordPlusHYDROQUINONE-
dc.subject.keywordPlusMITF-
dc.subject.keywordPlusACID-
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