DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Jeong Hee | ko |
dc.contributor.author | Kim, Kyung-Ah | ko |
dc.contributor.author | Shah, Amin | ko |
dc.contributor.author | Park, Byung Hyun | ko |
dc.contributor.author | Park, Woo Hyun | ko |
dc.contributor.author | Kim, Suhn Hee | ko |
dc.date.accessioned | 2024-03-25T01:01:48Z | - |
dc.date.available | 2024-03-25T01:01:48Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | PEPTIDES, v.31, no.5, pp.899 - 902 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318843 | - |
dc.description.abstract | Gap junction channels facilitate chemical and electrical communication between adjacent cells. Gap junction protein, connexin (Cx), is expressed in the endothelial cells of vessels, glomerulus, and renin-secreting cells of the kidney. The purpose of this study was to investigate the role of Cx in renin release using Cx-overexpressing As 4.1 cells. The adenovirus-induced Cx overexpression was conducted by using recombinant adenovirus containing the cDNA encoding Cx37, Cx40, Cx43 (Ad-Cx), and beta-galactosidase (Ad-beta-gal). In 40-overexpressing cells, basal renin release increased in a time-dependent manner but it was significantly lower than that in Ad-beta-gal-treated cells. In Cx37- and Cx43-overexpressing cells, basal renin release was increased in a time-dependent manner, which was not different from control cells. 18-beta glycyrrhetinic acid (GA), a gap junction blocker, stimulated renin release dose-dependently and increased intracellular Ca2+ in both Cx43-overexpressing cells and control cells. However, no significant differences were observed. An increase in renin release by 3,4,5-trimethoxybenzoic acid 8-(diethylamino)-octyl ester, a putative antagonist of Ca2+ release from intracellular sequestration sites, was also similar between two groups. These results suggest that Cx43 may unlikely alter the regulation of renin release and intracellular Ca2+ by gap junction blocker in As 4.1 cells. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Regulation of renin release by connexin 43 in As 4.1 cell line | - |
dc.type | Article | - |
dc.identifier.wosid | 000277768400016 | - |
dc.identifier.scopusid | 2-s2.0-77951258788 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 899 | - |
dc.citation.endingpage | 902 | - |
dc.citation.publicationname | PEPTIDES | - |
dc.identifier.doi | 10.1016/j.peptides.2010.02.014 | - |
dc.contributor.localauthor | Park, Byung Hyun | - |
dc.contributor.nonIdAuthor | Han, Jeong Hee | - |
dc.contributor.nonIdAuthor | Kim, Kyung-Ah | - |
dc.contributor.nonIdAuthor | Shah, Amin | - |
dc.contributor.nonIdAuthor | Park, Woo Hyun | - |
dc.contributor.nonIdAuthor | Kim, Suhn Hee | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | As 4.1 cell line | - |
dc.subject.keywordAuthor | Ca2+ | - |
dc.subject.keywordAuthor | Gap junction | - |
dc.subject.keywordAuthor | Hormone | - |
dc.subject.keywordAuthor | Renin | - |
dc.subject.keywordAuthor | Connexin | - |
dc.subject.keywordPlus | GAP JUNCTIONAL COMMUNICATION | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | INTERCELLULAR COMMUNICATION | - |
dc.subject.keywordPlus | NATRIURETIC PEPTIDE | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | HORMONE | - |
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