DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuan, Kuichang | ko |
dc.contributor.author | Kim, Sun Young | ko |
dc.contributor.author | Oh, Young-Bin | ko |
dc.contributor.author | Yu, Jiahua | ko |
dc.contributor.author | Shah, Amin | ko |
dc.contributor.author | Park, Byung Hyun | ko |
dc.contributor.author | Kim, Suhn Hee | ko |
dc.date.accessioned | 2024-03-25T01:01:35Z | - |
dc.date.available | 2024-03-25T01:01:35Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | PEPTIDES, v.31, no.7, pp.1319 - 1325 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318840 | - |
dc.description.abstract | Objectives: The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). Methods: Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anesthetized mice by tail cuff plethysmography and renal function was measured. Expression of ANP, natriuretic peptide receptor (NPR)-A, NPR-C, and tonicity-responsive enhancer binding protein (TonEBP) mRNA was determined by real-time PCR. Localization of I-125-ANP binding sites was measured using in vitro autoradiography. Results: In eNOS-/- mice, systolic blood pressure increased and left ventricular hypertrophy was observed. Urine volume and osmolarity did not change. Expression of ANP markedly increased in the heart and kidney of eNOS-/- mice. Expression of NPR-A and NPR-C increased in the heart and tended to increase in the kidney of eNOS-/- mice. In the renal medulla in particular, increased expression of NPR-C was more prominent. Expression of TonEBP mRNA was markedly decreased in the renal medulla, but not in the renal cortex. Maximum binding capacity (B-max) of ANP and C-ANP increased in the renal medulla in eNOS-/- mice. Conclusion: These results suggest that the eNOS-NO system may be partly involved in regulation of ANP, NPR-A, -C, and TonEBP mRNA expression in the kidney. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Upregulation of ANP and NPR-C mRNA in the kidney and heart of eNOS knockout mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000279078700013 | - |
dc.identifier.scopusid | 2-s2.0-77952544887 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1319 | - |
dc.citation.endingpage | 1325 | - |
dc.citation.publicationname | PEPTIDES | - |
dc.identifier.doi | 10.1016/j.peptides.2010.04.008 | - |
dc.contributor.localauthor | Park, Byung Hyun | - |
dc.contributor.nonIdAuthor | Yuan, Kuichang | - |
dc.contributor.nonIdAuthor | Kim, Sun Young | - |
dc.contributor.nonIdAuthor | Oh, Young-Bin | - |
dc.contributor.nonIdAuthor | Yu, Jiahua | - |
dc.contributor.nonIdAuthor | Shah, Amin | - |
dc.contributor.nonIdAuthor | Kim, Suhn Hee | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Medulla | - |
dc.subject.keywordAuthor | Osmolarity | - |
dc.subject.keywordAuthor | Blood pressure | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Natriuretic peptide receptor | - |
dc.subject.keywordAuthor | TonEBP | - |
dc.subject.keywordAuthor | Atrial natriuretic peptide | - |
dc.subject.keywordAuthor | Renal function | - |
dc.subject.keywordPlus | ATRIAL-NATRIURETIC-PEPTIDE | - |
dc.subject.keywordPlus | MEDULLARY COLLECTING DUCT | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CGMP PRODUCTION | - |
dc.subject.keywordPlus | RECEPTOR-A | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | OSMOREGULATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INDUCTION | - |
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