DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hwa-Suk | ko |
dc.contributor.author | Woo, Seong Ji | ko |
dc.contributor.author | Koh, Hyoung-Won | ko |
dc.contributor.author | Ka, Sun-O | ko |
dc.contributor.author | Zhou, Lu | ko |
dc.contributor.author | Jang, Kyu Yun | ko |
dc.contributor.author | Lim, Hye Song | ko |
dc.contributor.author | Kim, Hyun-Ok | ko |
dc.contributor.author | Lee, Sang-Il | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-25T01:00:39Z | - |
dc.date.available | 2024-03-25T01:00:39Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | ARTHRITIS AND RHEUMATISM, v.66, no.4, pp.863 - 873 | - |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318828 | - |
dc.description.abstract | Objective. Insulin-like growth factor binding protein 3 (IGFBP-3) is known to interfere with the NF-kappa B signaling pathway, and it effectively promotes apoptosis in tumor cells by a variety of mechanisms. NF-kappa B activation and apoptosis resistance of fibroblast-like synoviocytes (FLS) play pivotal roles in rheumatoid arthritis (RA). This study was undertaken to evaluate whether IGFBP-3 has antiarthritic effects. Methods. To deliver IGFBP-3, we used an adenovirus containing IGFBP-3 complementary DNA (AdIGFBP-3) or IGFBP-3 mutant that is devoid of IGF binding affinity but retains IGFBP-3 receptor binding ability (AdmtIGFBP-3). The regulatory roles of IGFBP-3 in inflammation and bone destruction were investigated in mice with collagen-induced arthritis (CIA). Results. IGFBP-3 levels were significantly higher in patients with RA than in those with osteoarthritis (OA) and were notably higher in patients with active RA. AdIGFBP-3 suppressed NF-kappa B activation, chemokine production, and matrix metalloproteinase secretion induced by tumor necrosis factor alpha (TNF alpha) in RA FLS. AdIGFBP-3 sensitized RA FLS to TNF alpha-induced apoptosis in vitro and also significantly increased apoptosis in an in vivo model of Matrigel implants engrafted into immunodeficient mice. AdIGFBP-3-injected mice with CIA had attenuated arthritis severity and reduced radiologic and pathologic abnormalities. Moreover, AdIGFBP-3 down-regulated local and systemic levels of NF-kappa B-targeted proinflammatory cytokines. Of note, RA FLS and mice with CIA treated with AdmtIGFBP-3 exhibited similar effects as those treated with AdIGFBP-3. Conclusion. Our results suggest that both the inflammatory response and bone destruction are reduced with blockage of NF-kappa B activation and induction of apoptosis in RA FLS by IGFBP-3. Therefore, IGFBP-3 may have therapeutic potential in RA. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Regulation of Apoptosis and Inflammatory Responses by Insulin-like Growth Factor Binding Protein 3 in Fibroblast-like Synoviocytes and Experimental Animal Models of Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.identifier.wosid | 000337361000012 | - |
dc.identifier.scopusid | 2-s2.0-84898623367 | - |
dc.type.rims | ART | - |
dc.citation.volume | 66 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 863 | - |
dc.citation.endingpage | 873 | - |
dc.citation.publicationname | ARTHRITIS AND RHEUMATISM | - |
dc.identifier.doi | 10.1002/art.38303 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Hwa-Suk | - |
dc.contributor.nonIdAuthor | Woo, Seong Ji | - |
dc.contributor.nonIdAuthor | Koh, Hyoung-Won | - |
dc.contributor.nonIdAuthor | Ka, Sun-O | - |
dc.contributor.nonIdAuthor | Zhou, Lu | - |
dc.contributor.nonIdAuthor | Jang, Kyu Yun | - |
dc.contributor.nonIdAuthor | Lim, Hye Song | - |
dc.contributor.nonIdAuthor | Kim, Hyun-Ok | - |
dc.contributor.nonIdAuthor | Lee, Sang-Il | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CARCINOMA CELLS | - |
dc.subject.keywordPlus | BONE DESTRUCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IGFBP-3 | - |
dc.subject.keywordPlus | DISEASE | - |
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