DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Lv, Na | ko |
dc.contributor.author | Kim, Eun-Kyung | ko |
dc.contributor.author | Kwon, Keun Sang | ko |
dc.contributor.author | Yoo, Young-Bum | ko |
dc.contributor.author | Kim, Jin-Hang | ko |
dc.contributor.author | Lee, Si-Woo | ko |
dc.contributor.author | Song, Je-Ho | ko |
dc.contributor.author | Lee, Jung-Han | ko |
dc.contributor.author | Lee, Su-Kyung | ko |
dc.contributor.author | Shin, Byung-Cheul | ko |
dc.contributor.author | Ryu, Do-Gon | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Kwon, Kang-Beom | ko |
dc.date.accessioned | 2024-03-22T07:04:08Z | - |
dc.date.available | 2024-03-22T07:04:08Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | JOURNAL OF MEDICINAL FOOD, v.12, no.2, pp.304 - 309 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318821 | - |
dc.description.abstract | We examined the effects of Rhizoma Dioscoreae Tokoronis extracts (RDTEs) on plasma lipids, body weight, and lipogenic enzymes. Mice were administered a standard chow diet, a 60% high-fat diet, or a high-fat diet with RDTE. Mice that were fed a high-fat diet containing RDTE were found to have lower increases in body and epididymal adipose tissue weights and a lessened occurrence of hepatic steatosis than mice that were fed a high-fat diet. The decreased adiposity that was induced by RDTE accounted for lower plasma levels of tumor necrosis factor-alpha, leptin, and glucose and a higher level of adiponectin. RDTE administration also resulted in a significant decrease in triglyceride, total plasma cholesterol, and low-density lipoprotein-cholesterol when compared to the high-fat group. To identify the mechanism by which RDTE induced its antiobesity effect, we investigated the sterol response element binding protein ( SREBP) transcription system, which was induced in mice that were fed the high-fat diet. RDTE was found to suppress the expression of SREBP-1 as well as that of fatty acid synthase in adipose and liver tissues in mice provided the high-fat diet. These findings suggest that the antiobesity action of RDTE in mice that are fed a high-fat diet may occur in response to suppression of the SREBP-1-dependent lipogenic pathway. | - |
dc.language | English | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Antiobesity Activity of Aqueous Extracts of Rhizoma Dioscoreae Tokoronis on High-Fat Diet-Induced Obesity in Mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000266279000009 | - |
dc.identifier.scopusid | 2-s2.0-67649526476 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 304 | - |
dc.citation.endingpage | 309 | - |
dc.citation.publicationname | JOURNAL OF MEDICINAL FOOD | - |
dc.identifier.doi | 10.1089/jmf.2008.1010 | - |
dc.identifier.kciid | ART001342576 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Lv, Na | - |
dc.contributor.nonIdAuthor | Kim, Eun-Kyung | - |
dc.contributor.nonIdAuthor | Kwon, Keun Sang | - |
dc.contributor.nonIdAuthor | Yoo, Young-Bum | - |
dc.contributor.nonIdAuthor | Kim, Jin-Hang | - |
dc.contributor.nonIdAuthor | Lee, Si-Woo | - |
dc.contributor.nonIdAuthor | Song, Je-Ho | - |
dc.contributor.nonIdAuthor | Lee, Jung-Han | - |
dc.contributor.nonIdAuthor | Lee, Su-Kyung | - |
dc.contributor.nonIdAuthor | Shin, Byung-Cheul | - |
dc.contributor.nonIdAuthor | Ryu, Do-Gon | - |
dc.contributor.nonIdAuthor | Kwon, Kang-Beom | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | antiobesity | - |
dc.subject.keywordAuthor | high-fat diet | - |
dc.subject.keywordAuthor | lipogenesis | - |
dc.subject.keywordAuthor | Rhizoma Dioscoreae Tokoronis | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | ACID SYNTHESIS | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
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