DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young-Rae | ko |
dc.contributor.author | Jin, Guo Hua | ko |
dc.contributor.author | Lee, Sang-Myeong | ko |
dc.contributor.author | Park, Jin-Woo | ko |
dc.contributor.author | Ryu, Jae-Ha | ko |
dc.contributor.author | Jeon, Raok | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T07:03:32Z | - |
dc.date.available | 2024-03-22T07:03:32Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.408, no.4, pp.625 - 629 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/318813 | - |
dc.description.abstract | The pathologic processes of rheumatoid arthritis are mediated by a number of cytokines, chemokines, and matrix metalloproteinases, the expressions of which are controlled by NF-kappa B. This study was performed to explore the effects of a benzothiazole analog, SPA0537, on the control of the NF-kappa B activation pathway. We also investigated whether SPA0537 had any anti-inflammatory effects in human rheumatoid fibroblast-like synoviocytes (FLS). SPA0537 inhibited the nuclear translocation and the DNA binding of NF-kappa B subunits, which correlated with the inhibitory effects on IKK phosphorylation and I kappa B alpha degradation in TNF-alpha-stimulated rheumatoid FLS. These events further suppressed chemokine production, matrix metalloproteinase secretion, and TNF-alpha-induced cell proliferation. In addition, SPA0537 inhibited the osteoclast differentiation induced by macrophage colony-stimulating factor (MCSF) and receptor activator of the NF-kappa B ligand (RANKL) in bone marrow macrophages. These findings suggest that SPA0537 exerts anti-inflammatory effects in rheumatoid FLS through the inhibition of the NF-kappa B pathway. Therefore, it may have therapeutic value for the treatment of rheumatoid arthritis. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Inhibition of TNF-α-mediated inflammatory responses by a benzodioxolylacetylamino-linked benzothiazole analog in human fibroblast-like synoviocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000291293200021 | - |
dc.identifier.scopusid | 2-s2.0-79956189825 | - |
dc.type.rims | ART | - |
dc.citation.volume | 408 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 625 | - |
dc.citation.endingpage | 629 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.04.073 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Young-Rae | - |
dc.contributor.nonIdAuthor | Jin, Guo Hua | - |
dc.contributor.nonIdAuthor | Lee, Sang-Myeong | - |
dc.contributor.nonIdAuthor | Park, Jin-Woo | - |
dc.contributor.nonIdAuthor | Ryu, Jae-Ha | - |
dc.contributor.nonIdAuthor | Jeon, Raok | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Synoviocytes | - |
dc.subject.keywordAuthor | RA | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | OSTEOCLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | CHEMOKINE | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | P50 | - |
dc.subject.keywordPlus | EXPRESSION | - |
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