DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Young-Bin | ko |
dc.contributor.author | Kim, Jong Hun | ko |
dc.contributor.author | Park, Byung Mun | ko |
dc.contributor.author | Park, Byung Hyun | ko |
dc.contributor.author | Kim, Suhn Hee | ko |
dc.date.accessioned | 2024-03-22T07:02:51Z | - |
dc.date.available | 2024-03-22T07:02:51Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | PEPTIDES, v.37, no.1, pp.79 - 85 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318804 | - |
dc.description.abstract | Angiotensin-(1-7) [Ang-(1-7)] plays a beneficial role in cardiovascular physiology by providing a counterbalance to the function of angiotensin II (Ang II). Although Ang II has been shown to be an adipokine secreted by adipocyte and affect lipid metabolism, the role of Ang-(1-7) in adipose tissue remains to be clarified. The aim of the present study was to investigate whether Ang-(1-7) affects lipid metabolism in adipose tissue. Ang-(1-7) increased glycerol release from primary adipocytes in a dose-dependent manner. A lipolytic effect of Ang-(1-7) was attenuated by pretreatment with A-779, a Mas receptor blocker and with an inhibitor of phosphoinositol 3-kinase (PI3K), or eNOS. However, losartan and PD123319 did not cause any change in Ang-(1-7)-induced lipolysis. Ang-(1-7)-induced lipolysis had an addictive effect with isoproterenol. In normal rats, chronic intake of captopril for 4 wks decreased body weight gain and the amount of adipose tissue and increased plasma Ang-(1-7) level. These effects were attenuated by administration of A-779. The levels of Mas receptor and phosphorylation of hormone-sensitive lipase (p-HSL) were significantly increased by treatment with captopril and these captopril-mediated effects were attenuated by the administration of A-779. There was no difference in diameter of adipocytes among sham, captopril- and captopril+A-779-treated groups. The similar effects of captopril on body weight, expression of Mas receptor, and p-HSL were observed in Ang-(1-7)-treated rats. These results suggest that captopril intake decreased body weight gain partly through Ang-(1-7)/Mas receptor/PI3K pathway. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Captopril intake decreases body weight gain via angiotensin-(1-7) | - |
dc.type | Article | - |
dc.identifier.wosid | 000308899100012 | - |
dc.identifier.scopusid | 2-s2.0-84865259212 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 79 | - |
dc.citation.endingpage | 85 | - |
dc.citation.publicationname | PEPTIDES | - |
dc.identifier.doi | 10.1016/j.peptides.2012.06.005 | - |
dc.contributor.localauthor | Park, Byung Hyun | - |
dc.contributor.nonIdAuthor | Oh, Young-Bin | - |
dc.contributor.nonIdAuthor | Kim, Jong Hun | - |
dc.contributor.nonIdAuthor | Park, Byung Mun | - |
dc.contributor.nonIdAuthor | Kim, Suhn Hee | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Adipocyte | - |
dc.subject.keywordAuthor | Lipolysis | - |
dc.subject.keywordAuthor | Angiotensin-(1-7) | - |
dc.subject.keywordAuthor | Captopril | - |
dc.subject.keywordAuthor | Hormone-sensitive lipase | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | RECEPTOR MAS | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | HUMAN ADIPOCYTES | - |
dc.subject.keywordPlus | OBESE MEN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LIPOLYSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
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