An 8-wk, randomized, double-blind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract

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Background: To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial. Methods: Impaired fasting glucose participants [fasting plasma glucose (FPG) >= 5.6mM or < 6.9mM] who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasma insulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic model assessment-beta) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs). Results: After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreased in the HGE group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does not produce noticeable adverse effects. Conclusion: HGE supplementation may be effective for treating impaired fasting glucose individuals. Copyright (C) 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.
Publisher
KOREAN SOC GINSENG
Issue Date
2014-10
Language
English
Article Type
Article
Citation

JOURNAL OF GINSENG RESEARCH, v.38, no.4, pp.239 - 243

ISSN
1226-8453
DOI
10.1016/j.jgr.2014.05.006
URI
http://hdl.handle.net/10203/318791
Appears in Collection
MSE-Journal Papers(저널논문)
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