DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, Seong Ji | ko |
dc.contributor.author | Lim, Kyu | ko |
dc.contributor.author | Park, Su Yeon | ko |
dc.contributor.author | Jung, Mun Yhung | ko |
dc.contributor.author | Lim, Hye Song | ko |
dc.contributor.author | Jeon, Min-Gyu | ko |
dc.contributor.author | Lee, Sang-Il | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T07:01:12Z | - |
dc.date.available | 2024-03-22T07:01:12Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.26, no.7, pp.713 - 720 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318783 | - |
dc.description.abstract | It is suggested that n-3 polyunsaturated fatty acids (PUFAs) can be used in the preventive or therapeutic management of rheumatoid arthritis (RA); however, controversial results have been reported. Here, we examined the effects of a decrease in the n-6/n-3 PUFA ratio on RA using fat-1 transgenic mice. First, we tested whether fat-1 expression modulated signaling pathways in fibroblast-like synoviocytes (FLSs) stimulated with tumor necrosis factor alpha (TNF-alpha). TNF-alpha activated p38 mitogen-activated protein kinase and increased phosphorylation of the signal transducer and activator of transcription 3 in wild type (WT) FLSs but not in fat-1 FLSs. Arthritis was induced by injection of K/BxN serum. Based on clinical scores, ankle thickness and pathological severity, we showed that WT mice developed clinically overt arthritis, whereas fat-1 mice showed attenuated arthritis. Moreover, fat-1 mice exhibited down-regulated local and systemic levels of inflammatory cytokines. Lastly, bone marrow-derived macrophages (BMMs) of WT mice differentiated into tartrate-resistant acid phosphatase-positive multinucleated osteoclasts, whereas the osteoclastogenenic process was suppressed in BMMs of fat-1 mice. The endogenous conversion of n-6 to n-3 PUFAs via fat-1 plays a key role in attenuation of RA; therefore, dietary supplementation of n-3 PUFAs may have therapeutic potential for the management of RA. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids attenuates K/BxN serum-transfer arthritis in fat-1 mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000356561600004 | - |
dc.identifier.scopusid | 2-s2.0-84937404766 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 713 | - |
dc.citation.endingpage | 720 | - |
dc.citation.publicationname | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jnutbio.2015.01.011 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Woo, Seong Ji | - |
dc.contributor.nonIdAuthor | Lim, Kyu | - |
dc.contributor.nonIdAuthor | Park, Su Yeon | - |
dc.contributor.nonIdAuthor | Jung, Mun Yhung | - |
dc.contributor.nonIdAuthor | Lim, Hye Song | - |
dc.contributor.nonIdAuthor | Jeon, Min-Gyu | - |
dc.contributor.nonIdAuthor | Lee, Sang-Il | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | n-3 PUFA | - |
dc.subject.keywordAuthor | RA | - |
dc.subject.keywordAuthor | fat-1 | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | K/BxN | - |
dc.subject.keywordPlus | FIBROBLAST-LIKE SYNOVIOCYTES | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | N-TERMINAL KINASE | - |
dc.subject.keywordPlus | FISH-OIL | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | BONE LOSS | - |
dc.subject.keywordPlus | P38 MAPK | - |
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