DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Wang, Jie | ko |
dc.contributor.author | Lee, Youngyi | ko |
dc.contributor.author | Lee, Juhyung | ko |
dc.contributor.author | Kwon, Keun-Sang | ko |
dc.contributor.author | Bae, Eun Ju | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T06:02:47Z | - |
dc.date.available | 2024-03-22T06:02:47Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | MOLECULAR NUTRITION FOOD RESEARCH, v.60, no.11, pp.2481 - 2492 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318745 | - |
dc.description.abstract | Scope: Diet-induced obesity and consequent insulin resistance are caused, in part, by macrophage polarization and accumulation in peripheral tissues. Here, we examined the effects of endogenously synthesized n-3 PUFAs on macrophage chemotaxis and polarization. Methods and results: Fat-1 mice and wild-type (WT) littermates were fed a 60% calorie high-fat diet (HFD) for 10 weeks. Bone marrow macrophages (BMMs) from fat-1 and WT mice were used in in vitro chemotaxis assays and macrophage polarization studies. WT mice fed a HFD exhibited glucose intolerance, insulin resistance, and lipid accumulation and macrophage infiltration in liver and adipose tissue. However, these metabolic and inflammatory phenotypes were not observed in HFD-fed fat-1 mice. In flow cytometric analysis, M1 macrophage infiltration into adipose tissue was markedly attenuated in fat-1 mice. Consistently, results from in vitro experiments indicated that n-3 PUFAs prevented adipocyte conditioned medium-mediated macrophage chemotaxis, stimulated M2 polarization, and suppressed M1 polarization. The inhibition of macrophage migration by n-3 PUFAs was associated with suppression of multiple kinases, such as I kappa B kinase, AKT, and focal adhesion kinase. Conclusion: Our results indicate that n-3 PUFAs play a crucial role in macrophage polarization and chemotaxis, and thus regulate the development of HFD-induced tissue inflammation and metabolic derangements. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Enhanced M2 macrophage polarization in high n-3 polyunsaturated fatty acid transgenic mice fed a high-fat diet | - |
dc.type | Article | - |
dc.identifier.wosid | 000389134200015 | - |
dc.identifier.scopusid | 2-s2.0-84978800354 | - |
dc.type.rims | ART | - |
dc.citation.volume | 60 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2481 | - |
dc.citation.endingpage | 2492 | - |
dc.citation.publicationname | MOLECULAR NUTRITION FOOD RESEARCH | - |
dc.identifier.doi | 10.1002/mnfr.201600014 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Wang, Jie | - |
dc.contributor.nonIdAuthor | Lee, Youngyi | - |
dc.contributor.nonIdAuthor | Lee, Juhyung | - |
dc.contributor.nonIdAuthor | Kwon, Keun-Sang | - |
dc.contributor.nonIdAuthor | Bae, Eun Ju | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Chemotaxis | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | n-3 PUFAs | - |
dc.subject.keywordAuthor | Polarization | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY-LINKED INFLAMMATION | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | FISH-OIL | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | IMPROVES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PHENOTYPE | - |
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