Enhanced M2 macrophage polarization in high n-3 polyunsaturated fatty acid transgenic mice fed a high-fat diet

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dc.contributor.authorSong, Mi-Youngko
dc.contributor.authorWang, Jieko
dc.contributor.authorLee, Youngyiko
dc.contributor.authorLee, Juhyungko
dc.contributor.authorKwon, Keun-Sangko
dc.contributor.authorBae, Eun Juko
dc.contributor.authorPark, Byung-Hyunko
dc.date.accessioned2024-03-22T06:02:47Z-
dc.date.available2024-03-22T06:02:47Z-
dc.date.created2024-03-21-
dc.date.created2024-03-21-
dc.date.issued2016-11-
dc.identifier.citationMOLECULAR NUTRITION FOOD RESEARCH, v.60, no.11, pp.2481 - 2492-
dc.identifier.issn1613-4125-
dc.identifier.urihttp://hdl.handle.net/10203/318745-
dc.description.abstractScope: Diet-induced obesity and consequent insulin resistance are caused, in part, by macrophage polarization and accumulation in peripheral tissues. Here, we examined the effects of endogenously synthesized n-3 PUFAs on macrophage chemotaxis and polarization. Methods and results: Fat-1 mice and wild-type (WT) littermates were fed a 60% calorie high-fat diet (HFD) for 10 weeks. Bone marrow macrophages (BMMs) from fat-1 and WT mice were used in in vitro chemotaxis assays and macrophage polarization studies. WT mice fed a HFD exhibited glucose intolerance, insulin resistance, and lipid accumulation and macrophage infiltration in liver and adipose tissue. However, these metabolic and inflammatory phenotypes were not observed in HFD-fed fat-1 mice. In flow cytometric analysis, M1 macrophage infiltration into adipose tissue was markedly attenuated in fat-1 mice. Consistently, results from in vitro experiments indicated that n-3 PUFAs prevented adipocyte conditioned medium-mediated macrophage chemotaxis, stimulated M2 polarization, and suppressed M1 polarization. The inhibition of macrophage migration by n-3 PUFAs was associated with suppression of multiple kinases, such as I kappa B kinase, AKT, and focal adhesion kinase. Conclusion: Our results indicate that n-3 PUFAs play a crucial role in macrophage polarization and chemotaxis, and thus regulate the development of HFD-induced tissue inflammation and metabolic derangements.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.titleEnhanced M2 macrophage polarization in high n-3 polyunsaturated fatty acid transgenic mice fed a high-fat diet-
dc.typeArticle-
dc.identifier.wosid000389134200015-
dc.identifier.scopusid2-s2.0-84978800354-
dc.type.rimsART-
dc.citation.volume60-
dc.citation.issue11-
dc.citation.beginningpage2481-
dc.citation.endingpage2492-
dc.citation.publicationnameMOLECULAR NUTRITION FOOD RESEARCH-
dc.identifier.doi10.1002/mnfr.201600014-
dc.contributor.localauthorPark, Byung-Hyun-
dc.contributor.nonIdAuthorSong, Mi-Young-
dc.contributor.nonIdAuthorWang, Jie-
dc.contributor.nonIdAuthorLee, Youngyi-
dc.contributor.nonIdAuthorLee, Juhyung-
dc.contributor.nonIdAuthorKwon, Keun-Sang-
dc.contributor.nonIdAuthorBae, Eun Ju-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorChemotaxis-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorMacrophage-
dc.subject.keywordAuthorn-3 PUFAs-
dc.subject.keywordAuthorPolarization-
dc.subject.keywordPlusADIPOSE-TISSUE INFLAMMATION-
dc.subject.keywordPlusOBESITY-LINKED INFLAMMATION-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusFISH-OIL-
dc.subject.keywordPlusIMMUNE-RESPONSES-
dc.subject.keywordPlusLIVER-DISEASE-
dc.subject.keywordPlusOMEGA-3-FATTY-ACIDS-
dc.subject.keywordPlusIMPROVES-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusPHENOTYPE-
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