DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Hyun-Young | ko |
dc.contributor.author | Koo, Jeung-Hyun | ko |
dc.contributor.author | Lee, Sang-Myeong | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T06:01:46Z | - |
dc.date.available | 2024-03-22T06:01:46Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.50 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318731 | - |
dc.description.abstract | Previous clinical trials have addressed the beneficial effects of fish oil supplementation on atopic dermatitis. Recently, we reported that fat-7 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed. Here, we examined the effects of endogenously synthesized n-3 PUFAs on atopic dermatitis, a representative Th2-dominant allergic inflammatory disease. Mouse models of atopic dermatitis-like skin lesions were prepared by epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) or house dust mite (HDM) extract to the ears. DNCB-treated fat-7 mice exhibited markedly reduced epidermal thickening, lower mast cell infiltration, and lower serum IgE and histamine compared with wild-type mice. The draining lymph nodes of fat-7 mice were substantially smaller and contained significantly smaller proportions of activated CD4(+) T cells and IL-4-producing Th2 cells than those of wild-type mice. Consistent with these findings, the mRNA levels of Th2 cytokines were significantly decreased in DNCB-sensitized skin lesions of fat-7 mice. Lastly, inflammasome activation, IL-1 beta production, and pyroptotic cell injury were suppressed in fat-7 mice. Similar results were observed in HDM-challenged fat-7 mice. This study confirms the results of previous clinical studies and suggests fish oil supplementation as a therapeutic strategy for atopic dermatitis-like skin lesions. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes | - |
dc.type | Article | - |
dc.identifier.wosid | 000436045700001 | - |
dc.identifier.scopusid | 2-s2.0-85058874570 | - |
dc.type.rims | ART | - |
dc.citation.volume | 50 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/s12276-018-0104-3 | - |
dc.identifier.kciid | ART002356421 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Jang, Hyun-Young | - |
dc.contributor.nonIdAuthor | Koo, Jeung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Sang-Myeong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | CELL ACTIVATION | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | TSLP | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
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