DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jeong-yeh | ko |
dc.contributor.author | Koo, Jeung-hyun | ko |
dc.contributor.author | Song, Young-gil | ko |
dc.contributor.author | Kwon, Kang-beom | ko |
dc.contributor.author | Lee, Ju-hyung | ko |
dc.contributor.author | Sohn, Hee-sook | ko |
dc.contributor.author | Park, Byung-hyun | ko |
dc.contributor.author | Jhee, Eun-chung | ko |
dc.contributor.author | Park, Jin-woo | ko |
dc.date.accessioned | 2024-03-22T05:02:00Z | - |
dc.date.available | 2024-03-22T05:02:00Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2006-11 | - |
dc.identifier.citation | ACTA PHARMACOLOGICA SINICA, v.27, no.11, pp.1467 - 1473 | - |
dc.identifier.issn | 1671-4083 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318708 | - |
dc.description.abstract | Aim: The effect of coumarin derivatives on melanogenesis was investigated in B16 murine melanoma cells. Methods: Melanin content and tyrosinase activity were analyzed spectrophotometrically. The expression of tyrosinase, tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were measured either by reverse transcription-polymerase chain reaction (RT-PCR) or Western blot. Results: Among the coumarin derivatives studied, scoparone (6,7-dimethoxycoumarin) was the most potent; the 6- or 7-methoxy group was found to be essential for the stimulation of melanogenesis. The melanin content was greatly increased by scoparone in a dose-dependent manner; there was no cytotoxicity at the effective concentrations. Scoparone increased enzyme activity as well as protein and mRNA expression of tyrosinase. In addition, mRNA of TRP-1 and TRP-2 were also increased after treatment with scoparone. H-89, an inhibitor of protein kinase A (PKA), completely inhibited the scoparone-induced increase of melanogenesis and the tyrosinase protein. Conclusion: These results suggest that scoparone-induced stimulation of melanogenesis is likely to occur at the transcriptional level of melanogenesis-related enzymes through PKA signaling. | - |
dc.language | English | - |
dc.publisher | ACTA PHARMACOLOGICA SINICA | - |
dc.title | Stimulation of melanogenesis by scoparone in B16 melanoma cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000241509500012 | - |
dc.identifier.scopusid | 2-s2.0-33750351969 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 1467 | - |
dc.citation.endingpage | 1473 | - |
dc.citation.publicationname | ACTA PHARMACOLOGICA SINICA | - |
dc.identifier.doi | 10.1111/j.1745-7254.2006.00435.x | - |
dc.contributor.localauthor | Park, Byung-hyun | - |
dc.contributor.nonIdAuthor | Yang, Jeong-yeh | - |
dc.contributor.nonIdAuthor | Koo, Jeung-hyun | - |
dc.contributor.nonIdAuthor | Song, Young-gil | - |
dc.contributor.nonIdAuthor | Kwon, Kang-beom | - |
dc.contributor.nonIdAuthor | Lee, Ju-hyung | - |
dc.contributor.nonIdAuthor | Sohn, Hee-sook | - |
dc.contributor.nonIdAuthor | Jhee, Eun-chung | - |
dc.contributor.nonIdAuthor | Park, Jin-woo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | scoparone (6,7-dimethoxy-coumarin) | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | tyrosinase-related proteins | - |
dc.subject.keywordAuthor | protein kinase A | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | 6,7-DIMETHOXYCOUMARIN | - |
dc.subject.keywordPlus | DIHYDROXYACETONE | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | GLYCYRRHIZIN | - |
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