DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ravichandiran, Palanisamy | ko |
dc.contributor.author | Prabakaran, D. S. | ko |
dc.contributor.author | Maroli, Nikhil | ko |
dc.contributor.author | Boguszewska-Czubara, Anna | ko |
dc.contributor.author | Maslyk, Maciej | ko |
dc.contributor.author | Kim, Ae Rhan | ko |
dc.contributor.author | Kolandaivel, Ponmalai | ko |
dc.contributor.author | Ramalingam, Prakash | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Han, Myung-Kwan | ko |
dc.contributor.author | Ramesh, Thiyagarajan | ko |
dc.contributor.author | Yoo, Dong Jin | ko |
dc.date.accessioned | 2024-03-22T03:00:30Z | - |
dc.date.available | 2024-03-22T03:00:30Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | JOURNAL OF HAZARDOUS MATERIALS, v.415 | - |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318656 | - |
dc.description.abstract | Several fluorescence and colorimetric chemosensory for Sn2+ detection in an aqueous media have been reported, but applications remain limited for discriminative Sn2+ detection in live human cells and zebrafish larvae. Herein, a mitochondria-targeted Sn2+ "turn-on" colorimetric and fluorescence chemosensor, 2CTA, with an aggregation-induced emission (AIE) response was developed. The sensing of Sn2+ was enabled by a reductionenabled binding pathway, with the conversion of -C=O groups to -C-OH groups at the naphthoquinone moiety. The color changed from light maroon to milky white in a buffered aqueous solution. The chemosensor 2CTA possessed the excellent characteristics of good water solubility, fast response (less than 10 s), and high sensitivity (79 nM) and selectivity for Sn2+ over other metal ions, amino acids, and peptides. The proposed binding mechanism was experimentally verified by means of FT-IR and NMR studies. The chemosensor 2CTA was successfully employed to recognize Sn2+ in live human cells and in zebrafish larvae. In addition, a colocalization study proved that the chemosensor had the ability to target mitochondria and overlapped almost completely with MitoTracker Red. Furthermore, a bioimaging study of live cells demonstrated the discriminative detection of Sn2+ in human cancer cells and the practical applications of 2CTA in biological systems. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.title | Mitochondria-targeted dual-channel colorimetric and fluorescence chemosensor for detection of Sn2+ ions in aqueous solution based on aggregation-induced emission and its bioimaging applications | - |
dc.type | Article | - |
dc.identifier.wosid | 000657737700003 | - |
dc.identifier.scopusid | 2-s2.0-85102387037 | - |
dc.type.rims | ART | - |
dc.citation.volume | 415 | - |
dc.citation.publicationname | JOURNAL OF HAZARDOUS MATERIALS | - |
dc.identifier.doi | 10.1016/j.jhazmat.2021.125593 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Ravichandiran, Palanisamy | - |
dc.contributor.nonIdAuthor | Prabakaran, D. S. | - |
dc.contributor.nonIdAuthor | Maroli, Nikhil | - |
dc.contributor.nonIdAuthor | Boguszewska-Czubara, Anna | - |
dc.contributor.nonIdAuthor | Maslyk, Maciej | - |
dc.contributor.nonIdAuthor | Kim, Ae Rhan | - |
dc.contributor.nonIdAuthor | Kolandaivel, Ponmalai | - |
dc.contributor.nonIdAuthor | Ramalingam, Prakash | - |
dc.contributor.nonIdAuthor | Han, Myung-Kwan | - |
dc.contributor.nonIdAuthor | Ramesh, Thiyagarajan | - |
dc.contributor.nonIdAuthor | Yoo, Dong Jin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Quinone | - |
dc.subject.keywordAuthor | Nanomolar | - |
dc.subject.keywordAuthor | Sensor probe | - |
dc.subject.keywordAuthor | Cellular colocalization | - |
dc.subject.keywordAuthor | Zebrafish larvae imaging | - |
dc.subject.keywordPlus | SENSITIVE DETECTION | - |
dc.subject.keywordPlus | STANNOUS FLUORIDE | - |
dc.subject.keywordPlus | SCHIFF-BASE | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | DENTIFRICE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | SN(II) | - |
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