DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong Gyun | ko |
dc.contributor.author | Song, Mi-Young | ko |
dc.contributor.author | Cho, Hwangeui | ko |
dc.contributor.author | Jin, Jong Sik | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Ju, Eun | ko |
dc.date.accessioned | 2024-03-22T01:00:26Z | - |
dc.date.available | 2024-03-22T01:00:26Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.citation | NUTRIENTS, v.14, no.19 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318627 | - |
dc.description.abstract | The purpose of this study was to examine whether Limonium tetragonum, cultivated in a smart-farming system with LED lamps, could increase exercise capacity in mice. C57BL/6 male mice were orally administered vehicle or Limonium tetragonum water extract (LTE), either 30 or 100 mg/kg, and were subjected to moderate intensity treadmill exercise for 4 weeks. Running distance markedly increased in the LTE group (100 mg/kg) by 80 +/- 4% compared to the vehicle group, which was accompanied by a higher proportion of oxidative fibers (6 +/- 6% vs. 10 +/- 4%). Mitochondrial DNA content and gene expressions related to mitochondrial biogenesis were significantly increased in LTE-supplemented gastrocnemius muscles. At the molecular level, the expression of PGC-1 alpha, a master regulator of fast-to-slow fiber-type transition, was increased downstream of the PKA/CREB signaling pathway. LTE induction of the PKA/CREB signaling pathway was also observed in C2C12 cells, which was effectively suppressed by PKA inhibitors H89 and Rp-cAMP. Altogether, these findings indicate that LTE treatment enhanced endurance exercise capacity via an improvement in mitochondrial biosynthesis and the increases in the formation of oxidative slow-twitch fibers. Future study is warranted to validate the exercise-enhancing effect of LTE in the human. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Limonium tetragonum Promotes Running Endurance in Mice through Mitochondrial Biogenesis and Oxidative Fiber Formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000866963300001 | - |
dc.identifier.scopusid | 2-s2.0-85139921985 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 19 | - |
dc.citation.publicationname | NUTRIENTS | - |
dc.identifier.doi | 10.3390/nu14193904 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Yong Gyun | - |
dc.contributor.nonIdAuthor | Song, Mi-Young | - |
dc.contributor.nonIdAuthor | Cho, Hwangeui | - |
dc.contributor.nonIdAuthor | Jin, Jong Sik | - |
dc.contributor.nonIdAuthor | Ju, Eun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Limonium tetragonum water extract | - |
dc.subject.keywordAuthor | smart-farming system | - |
dc.subject.keywordAuthor | endurance exercise | - |
dc.subject.keywordAuthor | mitochondrial biogenesis | - |
dc.subject.keywordAuthor | slow myofiber formation | - |
dc.subject.keywordAuthor | exercise mimetic | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | PGC-1-ALPHA TRANSCRIPTION | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | COACTIVATOR | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | TWITCH | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | RESPIRATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.