DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mone, Nishigandha S. | ko |
dc.contributor.author | Syed, Sahil | ko |
dc.contributor.author | Ravichandiran, Palanisamy | ko |
dc.contributor.author | Kamble, Ekta E. | ko |
dc.contributor.author | Pardesi, Karishma R. | ko |
dc.contributor.author | Salunke-Gawali, Sunita | ko |
dc.contributor.author | Rai, Mansi | ko |
dc.contributor.author | Singh, Ajay Vikram | ko |
dc.contributor.author | Dakua, Sarada Prasad | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Yoo, Dong Jin | ko |
dc.contributor.author | Satpute, Surekha K. | ko |
dc.date.accessioned | 2024-03-22T00:00:20Z | - |
dc.date.available | 2024-03-22T00:00:20Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | CHEMMEDCHEM, v.18, no.24 | - |
dc.identifier.issn | 1860-7179 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318615 | - |
dc.description.abstract | Antimicrobial resistance (AMR) interferes with the effective treatment of infections and increases the risk of microbial spread and infection-related illness and death. The synergistic activities of combinations of antimicrobial compounds offer satisfactory approaches to some extent. Structurally diverse naphthoquinones (NQs) including menadione (-CH3 group at C2) exhibit substantial antimicrobial activities against multidrug-resistant (MDR) pathogens. We explored the combinations of menadione with antibiotic ciprofloxacin or ampicillin against Staphylococcus aureus and its biofilms. We found an additive (0.5<FICI 1.0) and synergistic (FICI <= 0.5) effect of menadione with ciprofloxacin and ampicillin, respectively. High reactive oxygen species (ROS) activity and inhibition of biofilm formation (>90 %) were also observed. However, preformed biofilms were not affected. Dent formation was also evident in S. aureus treated with the test compounds. The structure-function relationship (SFR) of NQs was used to determine and predict their activity pattern against pathogens. Analysis of 10 structurally distinct NQs revealed that the compounds with -Cl, -Br, -CH3, or -OH groups displayed the lowest MICs (32-256 mu g/mL). Furthermore, 1,4-NQs possessing a halogen or -CH3 moiety showed elevated ROS activity, whereas molecules with an -OH group affected cell integrity. Improved activity of antimicrobial combinations and SFR approaches are significant in antimicrobial therapies. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Synergistic and Additive Effects of Menadione in Combination with Antibiotics on Multidrug-Resistant Staphylococcus aureus: Insights from Structure-Function Analysis of Naphthoquinones | - |
dc.type | Article | - |
dc.identifier.wosid | 001103227700001 | - |
dc.identifier.scopusid | 2-s2.0-85176252367 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 24 | - |
dc.citation.publicationname | CHEMMEDCHEM | - |
dc.identifier.doi | 10.1002/cmdc.202300328 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Mone, Nishigandha S. | - |
dc.contributor.nonIdAuthor | Syed, Sahil | - |
dc.contributor.nonIdAuthor | Ravichandiran, Palanisamy | - |
dc.contributor.nonIdAuthor | Kamble, Ekta E. | - |
dc.contributor.nonIdAuthor | Pardesi, Karishma R. | - |
dc.contributor.nonIdAuthor | Salunke-Gawali, Sunita | - |
dc.contributor.nonIdAuthor | Rai, Mansi | - |
dc.contributor.nonIdAuthor | Singh, Ajay Vikram | - |
dc.contributor.nonIdAuthor | Dakua, Sarada Prasad | - |
dc.contributor.nonIdAuthor | Yoo, Dong Jin | - |
dc.contributor.nonIdAuthor | Satpute, Surekha K. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Antimicrobial resistance | - |
dc.subject.keywordAuthor | menadione | - |
dc.subject.keywordAuthor | naphthoquinones | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | structure-function relationships | - |
dc.subject.keywordPlus | POLYMYXIN-B | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | BIOFILMS | - |
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