Simultaneous measurement of dynamic CBF and CSF signal changes with pseudo-continuous arterial spin labeling

Abstract

To measure CBF and CSF signals simultaneously, we proposed a new 2D EPI-based pCASL with overlapping portion of the labeling plane and imaging region. Our results showed that signal difference between label and control scans in the overlapping portion were higher in CSF than in other tissues. In addition, the pCASL-based CSF signals were negatively correlated with CBF, which was more significant than correlations of CBF with other tissues or baseline raw CSF signals. Based on the results, pCASL can be used for simultaneous measurement of dynamic CBF and CSF signal changes with our technique, which warrants further investigation.