Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation

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A high-sugar diet induces lifestyle-associated metabolic diseases, such as obesity and diabetes, which may un-derlie the pro-tumor effects of a high-sugar diet. We supply GL261 syngeneic glioblastoma (GBM) mice with a short-term high-glucose drink (HGD) and find an increased survival rate with no evidence of metabolic disease. Modulation of the gut microbiota through HGD supplementation is critical for enhancing the anti-tumor immune response. Single-cell RNA sequencing shows that gut microbiota modulation by HGD supplementation in-creases the T cell-mediated anti-tumor immune response in GBM mice. We find that the cytotoxic CD4+ T cell population in GBM is increased due to synergy with anti-programmed cell death protein 1 (anti-PD-1) im-mune checkpoint inhibitors, but this effect depends upon HGD supplementation. Thus, we determine that HGD supplementation enhances anti-tumor immune responses in GBM mice through gut microbiota modulation and suggest that the role of HGD supplementation in GBM should be re-examined.
Publisher
CELL PRESS
Issue Date
2023-10
Language
English
Article Type
Article
Citation

CELL REPORTS, v.42, no.10

ISSN
2211-1247
DOI
10.1016/j.celrep.2023.113220
URI
http://hdl.handle.net/10203/314849
Appears in Collection
MSE-Journal Papers(저널논문)
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