Tapered-slit membrane filter devices for the high-throughput viable isolation of circulating tumor cells

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We present tapered-slit filter devices for high-throughput viable circulating tumor cell (CTC) isolation and release. The membrane filter having an array of tapered-slits reduces the cell stress concentration at the edge of slit entrance, thus achieving viable CTC isolation with minimal stress. We fabricated the tapered-slit membrane from the UV exposure of spin-coated SU8 layers. The membrane filter device captures 82.44% of the cancer cells spiked in blood with the cell viability of 72.33% after 5 day culture of the captured cells; thus, allowing further molecular analysis and stable characterization of CTC for cancer diagnosis and prognosis.
Publisher
Chemical and Biological Microsystems Society
Issue Date
2014-10
Language
English
Citation

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, pp.467 - 469

URI
http://hdl.handle.net/10203/314267
Appears in Collection
BiS-Conference Papers(학술회의논문)
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