Cancer cell adhesion measurement on the collagen layer in multiple shear stress levels

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This paper presents a cell adhesion measurement chip with multiple shear stress zones in a single microchannel. In the experimental study, we used epithelial-like H358 and epithelial/mesenchymal-like A549 lung cancer cells to measure cell adhesion on the collagen layer. The detachment rate of H358 cells is 2∼4 times higher than that of A549 cells in the shear stress range of 34∼60dyne/cm2. The present chip is applicable to the quantitative analysis of tumor cell-extracellular matrix (ECM) adhesion.
Publisher
Chemical and Biological Microsystems Society
Issue Date
2014-10
Language
English
Citation

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, pp.1999 - 2001

URI
http://hdl.handle.net/10203/314266
Appears in Collection
BiS-Conference Papers(학술회의논문)
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