DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Woo-Sung | ko |
dc.contributor.author | Nam, Kyung-Ho | ko |
dc.contributor.author | Kim, Jong Hoon | ko |
dc.contributor.author | Kim, Won-Ju | ko |
dc.contributor.author | Kim, Jeong Eun | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Kim, Gil-Ran | ko |
dc.contributor.author | Choi, Je-Min | ko |
dc.date.accessioned | 2023-10-24T03:00:52Z | - |
dc.date.available | 2023-10-24T03:00:52Z | - |
dc.date.created | 2023-10-24 | - |
dc.date.created | 2023-10-24 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, v.14 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10203/313686 | - |
dc.description.abstract | Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play a key role in psoriasis pathogenesis, while regulatory T (Treg) cells are diminished during psoriatic inflammation. Current psoriasis treatments largely focus on IL-17 and IL-23, however, few studies have explored therapeutic drugs targeting an increase of Treg cells to control immune homeostasis. In this study, we investigated the effects of a cytotoxic T lymphocyte antigen-4 (CTLA-4) signaling peptide (dNP2-ctCTLA-4) in Th17, Tc17, gamma delta T cells, Treg cells in vitro and a mouse model of psoriasis. Treatment with dNP2-ctCTLA-4 peptide showed a significant reduction of psoriatic skin inflammation with increased Treg cell proportion and reduced IL-17 production by T cells, indicating a potential role in modulating psoriatic skin disease. We compared dNP2-ctCTLA-4 with CTLA-4-Ig and found that only dNP2-ctCTLA-4 ameliorated the psoriasis progression, with increased Treg cells and inhibited IL-17 production from gamma delta T cells. In vitro experiments using a T cell-antigen presenting cell co-culture system demonstrated the distinct mechanisms of dNP2-ctCTLA-4 compared to CTLA-4-Ig in the induction of Treg cells. These findings highlight the therapeutic potential of dNP2-ctCTLA-4 peptide in psoriasis by augmenting Treg/Teff ratio, offering a new approach to modulating the disease. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Alleviating psoriatic skin inflammation through augmentation of Treg cells via CTLA-4 signaling peptide | - |
dc.type | Article | - |
dc.identifier.wosid | 001077572100001 | - |
dc.identifier.scopusid | 2-s2.0-85173627173 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.publicationname | FRONTIERS IN IMMUNOLOGY | - |
dc.identifier.doi | 10.3389/fimmu.2023.1233514 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Lee, Woo-Sung | - |
dc.contributor.nonIdAuthor | Nam, Kyung-Ho | - |
dc.contributor.nonIdAuthor | Kim, Jong Hoon | - |
dc.contributor.nonIdAuthor | Kim, Won-Ju | - |
dc.contributor.nonIdAuthor | Kim, Jeong Eun | - |
dc.contributor.nonIdAuthor | Kim, Gil-Ran | - |
dc.contributor.nonIdAuthor | Choi, Je-Min | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | psoriasis | - |
dc.subject.keywordAuthor | dNP2-ctCTLA-4 | - |
dc.subject.keywordAuthor | CTLA-4-Ig | - |
dc.subject.keywordAuthor | Treg cells | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | CYTOPLASMIC DOMAIN | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | IMMUNOLOGY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | DELIVERY | - |
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