Various components in an engine nozzle are modeled as flexible multi-body components which are operated under high temperature and pressure. In this paper, in order to predict complex behavior of an engine nozzle, thermo-fluid-flexible multi-body dynamic coupled analysis framework was developed. Temperature and pressure on the nozzle wall were obtained by the CFD flow analysis for two-dimensional nozzle. The pressure and material properties according to temperature were delivered to DYMORE. Then nonlinear multi-body dynamics analysis was performed. Heat conduction and thermal analyses were conducted by MSC.NASTRAN. The present framework was validated for a simple nozzle configuration by using an one-way coupled analysis. Both-way coupled analysis was also performed for the simple nozzle with an imaginary joint clearance, and an asymmetric flow was observed. Finally, total strain result of a realistic nozzle configuration was obtained by the one-way and both-way coupled analyses.