DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sangbin | ko |
dc.contributor.author | Kim, Doyoung | ko |
dc.contributor.author | Yang, Wooil | ko |
dc.contributor.author | Han, Sunkyu | ko |
dc.date.accessioned | 2023-09-01T07:00:13Z | - |
dc.date.available | 2023-09-01T07:00:13Z | - |
dc.date.created | 2023-05-15 | - |
dc.date.created | 2023-05-15 | - |
dc.date.created | 2023-05-15 | - |
dc.date.created | 2023-05-15 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.citation | SYNLETT, v.35, no.5, pp.593 - 597 | - |
dc.identifier.issn | 0936-5214 | - |
dc.identifier.uri | http://hdl.handle.net/10203/312128 | - |
dc.description.abstract | We describe the first total synthesis of the C4-hydroxylated securinega alkaloids 4?-hydroxyallosecurinine and securingine F. The synthetic route features an Ellman's light-mediated hydrogen-atom transfer-based epimerization reaction that effectively sets the desired configuration at the C2 position. Simultaneous skeletal rearrangement from neosecurinane to securinane frameworks and stereochemical reversal at the C4 site was achieved under Mitsunobu reaction conditions. The C4-hydroxy group is envisioned to serve as a handle for potential biofunctional derivatizations. | - |
dc.language | English | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Total Synthesis of 4a-Hydroxyallosecurinine and Securingine F, Securinega Alkaloids with a C4-Hydroxy Handle for Biofunctional Derivatizations | - |
dc.type | Article | - |
dc.identifier.wosid | 000970530200002 | - |
dc.identifier.scopusid | 2-s2.0-85160736923 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 593 | - |
dc.citation.endingpage | 597 | - |
dc.citation.publicationname | SYNLETT | - |
dc.identifier.doi | 10.1055/a-2047-9680 | - |
dc.contributor.localauthor | Han, Sunkyu | - |
dc.contributor.nonIdAuthor | Kim, Doyoung | - |
dc.contributor.nonIdAuthor | Yang, Wooil | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | total synthesis | - |
dc.subject.keywordAuthor | securinega alkaloids | - |
dc.subject.keywordAuthor | biofunctional derivatizations | - |
dc.subject.keywordAuthor | hydroxyallosecurinine | - |
dc.subject.keywordAuthor | securingine F | - |
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