A highly infiltrative trait of glioblastoma multiforme (GBM) is a major challenge to treat the patients since remaining GBM cells end up developing recurrent tumors at postsurgical voids or different sites in a brain. To address this challenge, we thus suggest tumor capturing microbeads for postsurgical care. As a new therapeutic strategy, the microbeads could target remaining tumor cells by providing a tumor-adhesive surface. Reduction of the cell surfaces facilitates free thiols-mediated adhesion to microbeads, which enables entrapment of further cell invasion. Our tumor capturing microbeads may provide a brand-new proof-of-concept to complete treatment of infiltrative GBM.