DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyung Hwan | ko |
dc.contributor.author | Pyo, Hongryull | ko |
dc.contributor.author | Lee, Hoyoung | ko |
dc.contributor.author | Oh, Dongryul | ko |
dc.contributor.author | Noh, Jae Myoung | ko |
dc.contributor.author | Ahn, Yong Chan | ko |
dc.contributor.author | Kim, Chang Gon | ko |
dc.contributor.author | Yoon, Hong In | ko |
dc.contributor.author | Lee, Jiyun | ko |
dc.contributor.author | Park, Sehhoon | ko |
dc.contributor.author | Jung, Hyun-Ae | ko |
dc.contributor.author | Sun, Jong-Mu | ko |
dc.contributor.author | Lee, Se-Hoon | ko |
dc.contributor.author | Ahn, Jin Seok | ko |
dc.contributor.author | Park, Keunchil | ko |
dc.contributor.author | Ku, Bo mi | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Ahn, Myung-Ju | ko |
dc.date.accessioned | 2023-08-14T07:01:04Z | - |
dc.date.available | 2023-08-14T07:01:04Z | - |
dc.date.created | 2023-08-14 | - |
dc.date.created | 2023-08-14 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, v.115, no.2, pp.464 - 475 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311495 | - |
dc.description.abstract | Purpose: Associations between immunosenescence and radiation pneumonitis (RP) are largely unknown. We aimed to iden-tify a peripheral blood T cell senescence biomarker to predict RP in patients with non-small cell lung cancer (NSCLC). Methods and Materials: Patients with locally advanced NSCLC who received definitive concurrent chemoradiotherapy (dCRT) were prospectively registered (cohort 1, n=23; cohort 2, n=31). Peripheral blood was collected at baseline, during dCRT, and at 1 month post-dCRT. Patients were dichotomized to grade & GE;2 (G2+) RP and grade 0-1 (G0-1) RP. Flow cytometry was performed to assess phenotypes and functional properties of T cell subsets. RP incidence was estimated via competing risk analysis. Results: Five and six patients exhibited G2+ RP following dCRT in cohorts 1 and 2, respectively. Patients with G2+ RP exhib-ited a more aged T cell pool and higher frequencies of senescent CD57+CD28-CD8+ T cells than patients with G0-1 RP at baseline, during dCRT, and at 1 month post-dCRT. These senescent cells exhibited increased granzyme B, IFN-g, and TNF-a production. Higher baseline frequency of CD57+CD28-CD8+ T cells was an independent predictor of G2+ RP (hazard ratio, 8.42; 95% confidence interval, 2.58-27.45; P<0.001). Recursive partitioning analysis revealed three distinct risk groups strati-fied by baseline CD57+CD28-CD8+ T cell frequency and lung V20 Gy, with 1-year cumulative G2+ RP incidences of 50.0%, 16.7%, and 0% for high-, intermediate-, and low-risk groups, respectively (P=0.002).Conclusions: Higher baseline frequencies of CD57+CD28-CD8+ T cells correlated with increased G2+ RP risks. Our results suggest the need for further investigation of the role of T cell senescence on radiation-induced organ damage. & COPY; 2022 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Association of T Cell Senescence with Radiation Pneumonitis in Patients with Non-small Cell Lung Cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 001039823400001 | - |
dc.identifier.scopusid | 2-s2.0-85138540249 | - |
dc.type.rims | ART | - |
dc.citation.volume | 115 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 464 | - |
dc.citation.endingpage | 475 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.identifier.doi | 10.1016/j.ijrobp.2022.07.018 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Kyung Hwan | - |
dc.contributor.nonIdAuthor | Pyo, Hongryull | - |
dc.contributor.nonIdAuthor | Oh, Dongryul | - |
dc.contributor.nonIdAuthor | Noh, Jae Myoung | - |
dc.contributor.nonIdAuthor | Ahn, Yong Chan | - |
dc.contributor.nonIdAuthor | Kim, Chang Gon | - |
dc.contributor.nonIdAuthor | Yoon, Hong In | - |
dc.contributor.nonIdAuthor | Lee, Jiyun | - |
dc.contributor.nonIdAuthor | Park, Sehhoon | - |
dc.contributor.nonIdAuthor | Jung, Hyun-Ae | - |
dc.contributor.nonIdAuthor | Sun, Jong-Mu | - |
dc.contributor.nonIdAuthor | Lee, Se-Hoon | - |
dc.contributor.nonIdAuthor | Ahn, Jin Seok | - |
dc.contributor.nonIdAuthor | Park, Keunchil | - |
dc.contributor.nonIdAuthor | Ku, Bo mi | - |
dc.contributor.nonIdAuthor | Ahn, Myung-Ju | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | chemoradiotherapy | - |
dc.subject.keywordAuthor | non-small cell lung cancer | - |
dc.subject.keywordAuthor | peripheral blood | - |
dc.subject.keywordAuthor | radiation pneumonitis | - |
dc.subject.keywordAuthor | T cell senescence | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
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