DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, Hui | ko |
dc.contributor.author | Shi, Xiao-Jing | ko |
dc.contributor.author | Qi, Lin | ko |
dc.contributor.author | Wang, Cheng | ko |
dc.contributor.author | Mamtilahun, Muyassar | ko |
dc.contributor.author | Zhang, Zhi-Jun | ko |
dc.contributor.author | Chung, Won-Suk | ko |
dc.contributor.author | Yang, Guo-Yuan | ko |
dc.contributor.author | Tang, Yao-Hui | ko |
dc.date.accessioned | 2023-08-14T06:00:50Z | - |
dc.date.available | 2023-08-14T06:00:50Z | - |
dc.date.created | 2023-08-14 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | NEURAL REGENERATION RESEARCH, v.18, no.8, pp.1770 - 1776 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311484 | - |
dc.description.abstract | Recent studies have shown that microglia/macrophages and astrocytes can mediate synaptic phagocytosis through the MER proto-oncokinase in developmental or stroke models, but it is unclear whether the same mechanism is also active in traumatic brain injury. In this study, we established a mouse model of traumatic brain injury and found that both microglia/macrophages and astrocytes phagocytosed synapses and expression of the MER proto-oncokinase increased 14 days after injury. Specific knockout of MER in microglia/macrophages or astrocytes markedly reduced injury volume and greatly improved neurobehavioral function. In addition, in both microglia/macrophages-specific and astrocytes-specific MER knock-out mice, the number of microglia/macrophage and astrocyte phagocytosing synapses was markedly decreased, and the total number of dendritic spines was increased. Our study suggested that MER proto-oncokinase expression in microglia/macrophages and astrocytes may play an important role in synaptic phagocytosis, and inhibiting this process could be a new strategy for treating traumatic brain injury. | - |
dc.language | English | - |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | - |
dc.title | Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury | - |
dc.type | Article | - |
dc.identifier.wosid | 001036959100033 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1770 | - |
dc.citation.endingpage | 1776 | - |
dc.citation.publicationname | NEURAL REGENERATION RESEARCH | - |
dc.identifier.doi | 10.4103/1673-5374.363187 | - |
dc.contributor.localauthor | Chung, Won-Suk | - |
dc.contributor.nonIdAuthor | Shen, Hui | - |
dc.contributor.nonIdAuthor | Shi, Xiao-Jing | - |
dc.contributor.nonIdAuthor | Qi, Lin | - |
dc.contributor.nonIdAuthor | Wang, Cheng | - |
dc.contributor.nonIdAuthor | Mamtilahun, Muyassar | - |
dc.contributor.nonIdAuthor | Zhang, Zhi-Jun | - |
dc.contributor.nonIdAuthor | Yang, Guo-Yuan | - |
dc.contributor.nonIdAuthor | Tang, Yao-Hui | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordAuthor | astrocyte | - |
dc.subject.keywordAuthor | dendritic spines | - |
dc.subject.keywordAuthor | lysosome | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | MER proto-oncokinase | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | neurologic function | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | synapse engulfment | - |
dc.subject.keywordAuthor | traumatic brain injury | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | CELLS | - |
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