DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seok, Joon | ko |
dc.contributor.author | Cho, Sung-Dong | ko |
dc.contributor.author | Lee, Jeongsoo | ko |
dc.contributor.author | Choi, Yunseo | ko |
dc.contributor.author | Kim, Su-Young | ko |
dc.contributor.author | Lee, Sung-Min | ko |
dc.contributor.author | Kim, Sang-Hoon | ko |
dc.contributor.author | Jeong, Seongju | ko |
dc.contributor.author | Jeon, Minwoo | ko |
dc.contributor.author | Lee, Hoyoung | ko |
dc.contributor.author | Kim, A. Reum | ko |
dc.contributor.author | Choi, Baekgyu | ko |
dc.contributor.author | Ha, Sang-Jun | ko |
dc.contributor.author | Jung, Inkyung | ko |
dc.contributor.author | Yoon, Ki-Jun | ko |
dc.contributor.author | Park, Jong-Eun | ko |
dc.contributor.author | Kim, Jong Hoon | ko |
dc.contributor.author | Kim, Beom Joon | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.date.accessioned | 2023-08-09T01:00:51Z | - |
dc.date.available | 2023-08-09T01:00:51Z | - |
dc.date.created | 2023-07-27 | - |
dc.date.created | 2023-07-27 | - |
dc.date.created | 2023-07-27 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | NATURE IMMUNOLOGY, v.24, no.8, pp.1308 - 1317 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | http://hdl.handle.net/10203/311284 | - |
dc.description.abstract | Virtual memory T (T-VM) cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. Although T-VM cells have antiviral and antibacterial functions, whether these cells can be pathogenic effectors of inflammatory disease is unclear. Here we identified a T-VM cell-originated CD44(super-high(s-hi))CD49d(lo) CD8(+) T cell subset with features of tissue residency. These cells are transcriptionally, phenotypically and functionally distinct from conventional CD8(+) T-VM cells and can cause alopecia areata. Mechanistically, CD44(s-hi)CD49d(lo) CD8(+) T cells could be induced from conventional T-VM cells by interleukin (IL)-12, IL-15 and IL-18 stimulation. Pathogenic activity of CD44(s-hi)CD49d(lo) CD8(+) T cells was mediated by NKG2D-dependent innate-like cytotoxicity, which was further augmented by IL-15 stimulation and triggered disease onset. Collectively, these data suggest an immunological mechanism through which T-VM cells can cause chronic inflammatory disease by innate-like cytotoxicity. Virtual memory T cells have antimicrobial functions but whether they can contribute to inflammatory pathology is unclear. Here the authors show that a subset of CD8(+) T cells that originates from virtual memory T cells upon cytokine stimulation can drive the chronic inflammatory disease alopecia areata via innate-like cytotoxic effector functions. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | A virtual memory CD8(+) T cell-originated subset causes alopecia areata through innate-like cytotoxicity | - |
dc.type | Article | - |
dc.identifier.wosid | 001016469500001 | - |
dc.identifier.scopusid | 2-s2.0-85162925362 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1308 | - |
dc.citation.endingpage | 1317 | - |
dc.citation.publicationname | NATURE IMMUNOLOGY | - |
dc.identifier.doi | 10.1038/s41590-023-01547-5 | - |
dc.contributor.localauthor | Jung, Inkyung | - |
dc.contributor.localauthor | Yoon, Ki-Jun | - |
dc.contributor.localauthor | Park, Jong-Eun | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Kim, Su-Young | - |
dc.contributor.nonIdAuthor | Kim, Sang-Hoon | - |
dc.contributor.nonIdAuthor | Lee, Hoyoung | - |
dc.contributor.nonIdAuthor | Ha, Sang-Jun | - |
dc.contributor.nonIdAuthor | Kim, Jong Hoon | - |
dc.contributor.nonIdAuthor | Kim, Beom Joon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | REPERTOIRE | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | EPITOPES | - |
dc.subject.keywordPlus | CXCR3 | - |
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