DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kragl, Martin | ko |
dc.contributor.author | Schubert, Rajib | ko |
dc.contributor.author | Karsjens, Haiko | ko |
dc.contributor.author | Otter, Silke | ko |
dc.contributor.author | Bartosinska, Barbara | ko |
dc.contributor.author | Jeruschke, Kay | ko |
dc.contributor.author | Weiss, Juergen | ko |
dc.contributor.author | Chen, Chunguang | ko |
dc.contributor.author | Alsteens, David | ko |
dc.contributor.author | Kuss, Oliver | ko |
dc.contributor.author | Speier, Stephan | ko |
dc.contributor.author | Eberhard, Daniel | ko |
dc.contributor.author | Mueller, Daniel J. | ko |
dc.contributor.author | Lammert, Eckhard | ko |
dc.date.accessioned | 2023-08-01T01:01:10Z | - |
dc.date.available | 2023-08-01T01:01:10Z | - |
dc.date.created | 2023-08-01 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.7 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/310968 | - |
dc.description.abstract | An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells of mice results in glucose intolerance due to a loss of the intra-islet vasculature. In turn, blood vessels accumulate at the islet periphery. Neither alterations in endothelial cell proliferation, apoptosis, morphology, Vegfa expression and VEGF-A secretion nor 'empty sleeves' of vascular basement membrane are found. Instead, biophysical experiments reveal that the biomechanical properties of pancreatic islet cells, such as their actomyosin-mediated cortex tension and adhesive forces to endothelial cells, are significantly changed. These results suggest that a sorting event is driving the segregation of endothelial and epithelial cells and indicate that the epithelial biomechanical properties determine whether the blood vasculature invades or envelops a growing epithelial tissue. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The biomechanical properties of an epithelial tissue determine the location of its vasculature | - |
dc.type | Article | - |
dc.identifier.wosid | 000390049900001 | - |
dc.identifier.scopusid | 2-s2.0-85007002610 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms13560 | - |
dc.contributor.localauthor | Schubert, Rajib | - |
dc.contributor.nonIdAuthor | Kragl, Martin | - |
dc.contributor.nonIdAuthor | Karsjens, Haiko | - |
dc.contributor.nonIdAuthor | Otter, Silke | - |
dc.contributor.nonIdAuthor | Bartosinska, Barbara | - |
dc.contributor.nonIdAuthor | Jeruschke, Kay | - |
dc.contributor.nonIdAuthor | Weiss, Juergen | - |
dc.contributor.nonIdAuthor | Chen, Chunguang | - |
dc.contributor.nonIdAuthor | Alsteens, David | - |
dc.contributor.nonIdAuthor | Kuss, Oliver | - |
dc.contributor.nonIdAuthor | Speier, Stephan | - |
dc.contributor.nonIdAuthor | Eberhard, Daniel | - |
dc.contributor.nonIdAuthor | Mueller, Daniel J. | - |
dc.contributor.nonIdAuthor | Lammert, Eckhard | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | BETA-CELL MASS | - |
dc.subject.keywordPlus | CORTICAL TENSION | - |
dc.subject.keywordPlus | TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | INTERCELLULAR-ADHESION | - |
dc.subject.keywordPlus | DIFFERENTIAL ADHESION | - |
dc.subject.keywordPlus | FORCE SPECTROSCOPY | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | BLOOD-VESSELS | - |
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