DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Ihee, Hyotcherl | - |
dc.contributor.advisor | 이효철 | - |
dc.contributor.author | Lee, Yunbeom | - |
dc.date.accessioned | 2023-06-23T19:35:20Z | - |
dc.date.available | 2023-06-23T19:35:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=996431&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/309387 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 화학과, 2022.2,[iv, 93 p. :] | - |
dc.description.abstract | The molecular structures of various reaction intermediates generated during a chemical reaction play an important role in determining the reaction pathway and resulting products of a chemical reaction. For the past 20 years, the time-resolved X-ray solution scattering (TRXSS) has served as a key experimental method to visualize the structures of reaction intermediates generated during chemical reactions. With the emergence of X-ray free electron lasers (XFELs), the structural dynamics even within 100 ps became accessible using femtosecond-TRXSS (fs-TRXSS) with the aid of the X-ray pulse generated by XFELs. However, there has been a limited number of examples of ultrafast structural dynamics studies on proteins using TRXSS. Here, I present the ultrafast structural dynamics of the proteins revealed by fs-TRXSS. Via fs-TRXSS, a distinct reaction intermediate, which was not observed in the previous studies due to the insufficient time resolution, was identified. In addition, unique ultrafast structural dynamics of a protein, such as the coherent motion, and the change of the hydration shell surrounding the protein were successfully captured. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Investigation of ultrafast structural dynamics of proteins using time-resolved X-ray solution scattering | - |
dc.title.alternative | 시간분해 엑스선 용액상 산란법을 이용한 단백질의 초고속 구조 동역학 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 이윤범 | - |
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